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首页> 外文期刊>ACS applied materials & interfaces >Wool/Acrylic Blended Fabrics as Next-Generation Photodynamic Antimicrobial Materials
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Wool/Acrylic Blended Fabrics as Next-Generation Photodynamic Antimicrobial Materials

机译：羊毛/丙烯酸混纺织物作为下一代光动力学抗菌材料

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The adoption of self-sterilizing materials to reduce infection transmission in hospitals and related healthcare facilities has been hampered by the availability of scalable, cost-effective, and potent antimicrobial textiles. Here, we investigated whether photodynamic materials comprising photosensitizer-embedded wool/acrylic blends were able to mediate the photodynamic inactivation of Gram-positive and Gram-negative bacteria. A small library of wool/acrylic (W/A) blended fabrics was constructed wherein the wool fibers were embedded with rose Bengal (RB) as a photosensitizer and the acrylic fibers were dyed with a traditional cationic yellow X-8GL dye, thereby enabling a broader color palette than was achievable with a single photosensitizer. The resultant photodynamic materials were characterized by physical (SEM, DSC, TGA, tensile strength), spectroscopic (fluorescence), colorimetric (K/S and CIELab values), and color fastness (against rubbing, washing) studies, and their photooxidation of the model substrate potassium iodide demonstrated the ability of these materials to generate microbicidal reactive oxygen species (i.e., singlet oxygen) upon illumination. Our best results yielded the photodynamic inactivation of Gram-positive S. aureus (99.98%) and B. subtilis (99.993%) by similar to 4 log units upon illumination with visible light (60 min; 65 +/- 5 mW/cm(2); lambda >= 420 nm), although more modest activity was observed against Gram-negative P. aeruginosa and E. coli (1-2 log units pathogen reduction). While there were no statistically significant differences for dual-dyed materials that were produced through either sequential or simultaneous dyeing steps, it was noted that high loadings of the cationic yellow X-8GL dye did inhibit the antimicrobial activity of the RB photosensitizer, with the dual-dyed materials able to mediate a 2.9 log unit reduction against S. aureus at a 1% o.w.f X-8GL loading. These findings indicate that the antimicrobial photodynamic inactivation of dual-dyed materials is independent of the dyeing process itself, yet exhibits limitations on the loading of the traditional dye with regards to the activity of the photosensitizer. Taken together, the results suggest the feasibility of photosensitizer-embedded blended fabrics produced through a one-step dyeing process as a low-cost and scalable method for creating effective self-disinfecting textiles for infection prevention, and whose inclusion of a second traditional dye for color variation will further benefit their adoption from a commercial standpoint.
机译：通过可释放，经济高效和有效的抗菌纺织品的可用性，采用自燃材料以减少医院和相关医疗保健设施的感染传播。在这里，我们研究了包含光敏剂嵌入的羊毛/丙烯酸共混物的光动力学材料是否能够介导革兰氏阳性和革兰氏阴性细菌的光动力灭活。构建了一小部分羊毛/丙烯酸（W / A）混合织物，其中将羊毛纤维嵌入玫瑰叶（Rb）中，作为光敏剂，用传统的阳离子黄x-8gl染料染色丙烯酸纤维，从而使A更广泛的调色板比单一光敏剂可实现。由物理（SEM，DSC，TGA，拉伸强度），光谱（荧光），比色（K / S和CIELAB值），以及色牢度（针对摩擦，洗涤）研究以及它们的光氧化，以及它们的光氧化模型底物碘化钾证明了这些材料在照明时产生微生物反应性氧物质（即单次氧）的能力。我们的最佳结果产生了通过可见光照明（60分钟; 65 +/- 5 MW / cm（ 2）; Lambda> = 420nm），虽然针对克克阴性P.铜绿假单胞菌和大肠杆菌（1-2对数组病原体降低）观察到更温和的活性。虽然通过顺序或同时染色步骤产生的双染料材料没有统计学显着的差异，但注意到阳离子黄X-8GL染料的高负荷确实抑制了RB光敏剂的抗微生物活性与双重的能够以1％OWF X-8GL负载介导2.9木制单位减少的2.9木制单位的材料。这些发现表明，双染料材料的抗微生物光动力动力灭活是独立于染色过程本身的染色过程，但对光敏剂的活性表现出传统染料的负载的限制。结果表明，通过单步染色过程产生的光敏剂嵌入式混合织物的可行性，作为一种低成本和可扩展的方法，用于制造有效的自消毒纺织品进行感染预防，其包含第二种传统染料颜色变异将进一步受益于他们从商业角度的采用。

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