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首页> 外文期刊>ACS applied materials & interfaces >Novel ZnO/N-halamine-Mediated Multifunctional Dressings as Quick Antibacterial Agent for Biomedical Applications
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Novel ZnO/N-halamine-Mediated Multifunctional Dressings as Quick Antibacterial Agent for Biomedical Applications

机译：新型ZnO / N-卤化介导的多功能敷料作为生物医学应用的快速抗菌剂

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摘要

Cutaneous hemorrhage often occurs in daily life which may cause infection and even amputation. This research aims to develop a novel chitosan dressing impregnated with ZnO/N-halamine hybrid nanoparticles for quick antibacterial performance, outstanding hemostatic potential, high porosity, and favorable swelling property through combining sonication and lyophilization processing. After 30 days of storage, about 90% bacterial cell viability loss could be observed toward both Gram-positive Staphylococcus aureus and Gram-negative Escherichia soli O157:H7 within 30 min of contact by colony counting method. The hybrids assembled much more platelet and red blood cell as compared with pure chitosan control. Moreover, the lower blooding clotting index value gave evidence that these composites could control hemorrhaging and reduce the probability of wound infection. No potential skin irritation and toxicity were detected using in vitro cytocompatibility and a skin stimulation test. Therefore, this work demonstrated a facile and cost-effective approach for the preparation of N-halamine-based hybrid sponges which show promising application for wound dressings.
机译：皮肤出血通常发生在日常生活中，这可能导致感染甚至截肢。本研究旨在通过组合超声处理和冻干加工，开发浸渍有ZnO / N-卤素杂化纳米粒子的新型壳聚糖敷料，用于快速抗菌性能，出色的止血潜力，高孔隙度和良好的溶胀性。在储存30天后，可以在菌落计数方法30分钟内朝向革兰酰基阳性葡萄球菌和革兰氏阴性葡萄球菌和革兰氏阴性大肠杆菌和革兰氏阴性大肠杆菌溶液和革兰氏阴性大肠杆菌溶液O157：H7。与纯壳聚糖对照相比，杂交种组装了更多的血小板和红细胞。此外，较低的血液凝血指数值给出了这些复合材料可以控制出血并降低伤口感染的可能性。使用体外细胞膜相容性和皮肤刺激测试没有检测到潜在的皮肤刺激和毒性。因此，这项工作表明了一种适用于制备基于N-卤化的混合海绵的成本效益的方法，其显示有前途的伤口敷料施用。

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  • 来源
    《ACS applied materials & interfaces》 |2019年第34期|共10页
  • 作者

    Ma Wei; Li Lin; Lin Xinghuan; Wang Yingfeng; Ren Xuehong; Huang Tung-Shi;

  • 作者单位

    Jiangnan Univ Coll Text &

    Clothing Key Lab Ecotext Minist Educ Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Coll Text &

    Clothing Key Lab Ecotext Minist Educ Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Coll Text &

    Clothing Key Lab Ecotext Minist Educ Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Coll Text &

    Clothing Key Lab Ecotext Minist Educ Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Coll Text &

    Clothing Key Lab Ecotext Minist Educ Wuxi 214122 Jiangsu Peoples R China;

    Auburn Univ Dept Poultry Sci Auburn AL 36849 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    ZnO; N-halamine; chitosan dressing; antibacterial; cytocompatibility;

    机译：ZnO;N-卤素;壳聚糖敷料;抗菌;细胞偶联;

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