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首页> 外文期刊>ACS applied materials & interfaces >Novel Oxygen-Deficient Zirconia (ZrO2–x) for Fluorescence/Photoacoustic Imaging-Guided Photothermal/Photodynamic Therapy for Cancer
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Novel Oxygen-Deficient Zirconia (ZrO2–x) for Fluorescence/Photoacoustic Imaging-Guided Photothermal/Photodynamic Therapy for Cancer

机译：用于荧光/光声成像引导的光热/光动力治疗的新型氧缺氧氧化锆（ZrO2-X）

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摘要

Theranostic nanoplatforms that integrate therapy and diagnosis in a single composite have become increasingly attractive in the field of precise and efficient tumor treatment. Herein, a novel oxygen-deficient zirconia (ZrO_(2–x )) nanosystem based on the conjugation of thiol-polyethylene glycol-amine (SH-PEG-NH_(2)) and chlorin e6 (Ce6) was elaborately designed and established for efficacious photothermal/photodynamic therapy (PTT/PDT) and fluorescence/photoacoustic (FL/PA) bimodal imaging for the first time. The crystalline-disordered, PEGylated ZrO_(2–x ) nanoparticles (ZP NPs) displayed strong optical absorption in the near-infrared (NIR) window and were featured with significant photothermal conversion capacity. The ZP NPs were further covalently conjugated with Ce6 to form ZrO_(2–x )@PEG/Ce6 (ZPC) NPs, which displayed a long circulatory half-life, efficient tumor accumulation, and outstanding FL/PA imaging performance. Moreover, the nanocomposites effectively generated cytotoxic intracellular reactive oxygen species (ROS) responsive to laser activation. Both cell studies and animal experiments explicitly demonstrated that ZPC NPs mediated remarkable tumor ablation with minimal systemic toxicity thanks to their tumor-specific PTT/PDT effect. Collectively, these findings may open up new avenues to broaden the application of oxygen-deficient ZrO_(2–x ) nanostructures as high-performance photothermal agents in tumor theranostics through rational design and accurate control of their physiochemical properties.
机译：在精确高效的肿瘤治疗领域，整合治疗和诊断整合治疗和诊断的治疗纳米纳薄表现越来越有吸引力。在本文中，精致设计了基于硫醇 - 聚乙二醇 - 胺（SH-PEG-NH_（2））和氯E6（CE6）的共轭的新型氧缺氧氧化锆（ZrO_（2-β））纳米系统并且第一次建立有效的光热/光动力治疗（PTT / PDT）和荧光/光声（FL / PA）双峰成像。结晶无序的聚乙二醇化ZrO_（2- X）纳米颗粒（ZP NPS）在近红外（NIR）窗口中显示出强光学吸收，并具有显着的光热转换能力。 ZP NPS与CE6进一步与CE6共价缀合，形成ZrO_（2- x）@ PEG / CE6（ZPC）NPS，其显示出长循环的半衰期，高效肿瘤累积和出色的FL / PA成像性能。此外，纳米复合材料响应于激光活化而有效地产生细胞毒细胞内反应性氧物质（ROS）。细胞研究和动物实验都明确证明ZPC NPS由于其肿瘤特异性PTT / PDT效应而介导具有最小的全身毒性的显着肿瘤消融。总的来说，这些发现可以通过合理的设计和精确控制它们的理化性质，打开新的途径，以扩大缺氧ZrO_（2- x（2-

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  • 来源
    《ACS applied materials & interfaces》 |2019年第44期|共13页
  • 作者

    Lihong Sun; Xiaodan Jiao; Weiwei Liu; Ying Wang; Yang Cao; Shu-Juan Bao; Zhigang Xu; Yuejun Kang; Peng Xue;

  • 作者单位

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry Ministry of Education School of Materials and Energy Southwest University;

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry Ministry of Education School of Materials and Energy Southwest University;

    Chongqing Key Laboratory of Ultrasound Molecular Imaging Institute of Ultrasound Imaging Second Affiliated Hospital Chongqing Medical University;

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry Ministry of Education School of Materials and Energy Southwest University;

    Chongqing Key Laboratory of Ultrasound Molecular Imaging Institute of Ultrasound Imaging Second Affiliated Hospital Chongqing Medical University;

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry Ministry of Education School of Materials and Energy Southwest University;

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry Ministry of Education School of Materials and Energy Southwest University;

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry Ministry of Education School of Materials and Energy Southwest University;

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry Ministry of Education School of Materials and Energy Southwest University;

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  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    oxygen-deficient zirconia; nanomedicine; multimodal imaging; photothermal therapy; cancer theranostics;

    机译：氧缺氧氧化锆;纳米医生;多式化成像;光热疗;癌症治疗;

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