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首页> 外文期刊>ACS applied materials & interfaces >Biomimetic Pulsating Vesicles with Both pH-Tunable Membrane Permeability and Light-Triggered Disassembly-Re-assembly Behaviors Prepared by Supra-Amphiphilic Helices
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Biomimetic Pulsating Vesicles with Both pH-Tunable Membrane Permeability and Light-Triggered Disassembly-Re-assembly Behaviors Prepared by Supra-Amphiphilic Helices

机译：通过Supra-Amphiphici智能螺旋制备的pH可调谐膜渗透性和光触发的拆卸重组行为的仿生脉动囊泡

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摘要

The reversible unfolding-refolding transition is considerably important for natural elastomeric proteins (e.g., titin) to fulfill their biological functions. It is of great importance to develop synthetic versions by borrowing their unique stretchable design principles. Herein, we present a novel pulsating vesicle by means of the aqueous self-assembly of supra-amphiphilic helices. Interestingly, this vesicle simultaneously features dynamic swelling and shrinkage movements in response to external proton triggers. Titin-like unfolding-refolding transformation of artificial helices was proved to play a crucial role in this pulsatile motion. Moreover, the vesicular membrane of this vesicle has exhibited tunable permeability during reversible expansion and contraction circulation. Meanwhile, light can also be used as a driving force to further regulate the disassembly-reassembly transformation of the pulsating vesicle. In addition, the drug delivery system was also employed as an investigating model to estimate the permeability variation and disassembly-reassembly behaviors of the pulsating vesicles, which displayed unique dual quick- and sustained-release behaviors toward anti-cancer agents. It is anticipated that this work opens an avenue for fabricating novel stretchable biomimetics by using the exclusive unfolding-refolding nature of artificial foldamers.
机译：可逆展开重折叠过渡对于天然弹性蛋白（例如，三肽）非常重要，以满足其生物学功能。通过借用独特的可拉伸设计原则开发合成版本非常重要。在此，我们通过逐个两亲螺旋的含水自组装呈现新型脉动囊泡。有趣的是，这种囊泡同时具有响应于外部质子触发的动态膨胀和收缩运动。证明人工螺旋的刺激式展开转换在这种脉动运动中起着至关重要的作用。此外，该囊泡的凹凸膜在可逆膨胀和收缩循环期间表现出可调性渗透性。同时，光也可以用作驱动力以进一步调节腐蚀囊泡的拆卸重组转换。此外，药物递送系统也用作调查模型，以估计脉动囊泡的渗透性变化和拆卸 - 重组行为，其朝向抗癌剂显示独特的双重快速和持续释放行为。预计这项工作是通过使用人造糊涂虫的独家展开重折叠性质，打开制造新型可拉伸生物体的途径。

著录项

  • 来源
    《ACS applied materials & interfaces》 |2019年第34期|共9页
  • 作者

    Yan Tengfei; Li Fei; Tian Jun; Wang Liang; Luo Quan; Hou Chunxi; Dong Zeyuan; Xu Jiayun; Liu Junqiu;

  • 作者单位

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat 2699 Qjanjin St Changchun 130012 Jilin Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    pulsating vesicle; self-assembly; supra-amphiphilic helix; unfolding-refolding; sustained-release;

    机译：脉动囊泡;自我组装;上半年螺旋;展开 - 重折叠;持续释放;

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