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首页> 外文期刊>ACS applied materials & interfaces >Green Tea Polyphenol Induced Mg2+-rich Multilayer Conversion Coating: Toward Enhanced Corrosion Resistance and Promoted in Situ Endothelialization of AZ31 for Potential Cardiovascular Applications
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Green Tea Polyphenol Induced Mg2+-rich Multilayer Conversion Coating: Toward Enhanced Corrosion Resistance and Promoted in Situ Endothelialization of AZ31 for Potential Cardiovascular Applications

机译：绿茶多酚诱导Mg2 + -RICH多层转化涂料：朝向增强的耐腐蚀性，并促进AZ31的原位内皮，用于潜在的心血管应用

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As a promising biodegradable metallic material, magnesium (Mg) and its alloys have attracted special attention in the recent decade. However, challenges still remain due to its high corrosion rate and insufficient biocompatibility after implantation. In this work, we prepare a simple and versatile green tea phenol–metal induced multilayer conversion coating (Mg~(2+) incorporated epigallocatechin gallate (EGCG) coating) on magnesium alloys’ (AZ31) substrate by layer-by-layer (LBL) method. The surface morphology results revealed that, with the incorporation of Mg~(2+), the as-formed EGCG/Mg coating was rich in phenol–Mg complex and presented more homogeneous and dense morphology, with far less cracks than the pure EGCG coating. The in vitro degradation rate and corrosion resistance were studied by electrochemical corrosion tests and monitoring of the changed pH value and hydrogen evolution, respectively, which revealed that the corrosion rate was effectively decreased compared to that of bare AZ31 after it was protected by EGCG/Mg coating. In vitro and ex vivo thrombogenicity test demonstrated the EGCG/Mg coatings presented an impressive improvement in decreasing the adhesion and activation of platelets and erythrocytes, in activated partial thromboplastin time (APTT), and in antithrombogenicity compared to those of bare AZ31. Owing to the mild degradation rate, in combination with the biological function of EGCG, enhanced endothelial cells’ (ECs’) adhesion and proliferation, suppressed smooth muscle cells’ (SMCs’) adhesion/proliferation, and inhibited cytokine release were observed on EGCG/Mg coated AZ31 alloy. Besides, the in vivo subcutaneous embedding experiment suggested that the EGCG/Mg coating performed more mild tissue response due to the improved corrosion resistance to the surrounding microenvironment. Moreover, for in vivo abdominal aorta assay, the EGCG/Mg coated AZ31 wire presented better corrosion resistance and enhanced re-endothelialization compared to bare AZ31 wire. These results suggested the potential of using green tea polyphenol induced Mg~(2+)-rich multilayer conversion coating for enhanced corrosion protection and desired biocompatibility of biodegradable cardiovascular implants.
机译：作为有前途的可生物降解的金属材料，镁（Mg）及其合金在近十年来引起了特别的关注。然而，挑战仍然是由于其高腐蚀速率和植入后的生物相容性不足。在这项工作中，我们制备简单而通用的绿茶酚醛金属诱导的多层转化涂层（Mg〜（2+）通过层上镁合金'（AZ31）底物上的EpigallocateChin Gallate（EGCG）涂层）（LBL ） 方法。表面形态结果表明，随着Mg〜（2+）的掺入，富含酚-mg络合物中富含富含酚类和致密的形态，具有比纯EGCG涂层更少的裂缝呈富含均匀和致密的形态。通过电化学腐蚀试验和监测改变的pH值和氢气进化的体外降解速率和耐腐蚀性，这揭示了与EGCG / MG保护后的裸AZ31相比有效地降低了腐蚀速率涂层。体外和离体血栓形成性测试证明EGCG / Mg涂层呈现出令人印象深刻的改进，降低血小板和红细胞的粘附性和激活，与裸AZ31相比，抗血栓形成性和抗血栓形成性。由于轻度降解率，与EGCG的生物学功能相结合，增强内皮细胞'（ECS）粘附和增殖，抑制平滑肌细胞'（SMC）的粘附/增殖，并在EGCG上观察到细胞因子释放和抑制细胞因子释放。 Mg涂层AZ31合金。此外，体内皮下嵌入实验表明，由于对周围微环境的耐腐蚀性改善，EGCG / Mg涂层由于改善了耐腐蚀性而进行了更温和的组织响应。此外，对于体内腹主动脉测定，与裸AZ31线相比，EGCG / Mg涂覆的AZ31线呈现更好的耐腐蚀性和增强的重新内皮化。这些结果表明使用绿茶多酚诱导的Mg〜（2 +）的多层转化涂层的潜力，以提高可生物降解的心血管植入物的腐蚀保护和所需的生物相容性。

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