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首页> 外文期刊>ACS applied materials & interfaces >Artemisinin-Based Smart Nanomedicines with Self-Supply of Ferrous Ion to Enhance Oxidative Stress for Specific and Efficient Cancer Treatment
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Artemisinin-Based Smart Nanomedicines with Self-Supply of Ferrous Ion to Enhance Oxidative Stress for Specific and Efficient Cancer Treatment

机译：基于青蒿素的智能纳米海内西红霉，具有亚铁离子的自供应，可增强特定和有效的癌症治疗的氧化应激

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摘要

Though abundant researches report that artemisinin could inhibit cancer cell growth via generating toxic reactive oxygen species (ROS), the therapeutic efficiency of artemisinin for cancer treatment is still limited owing to the insufficient intracellular ferrous ion and defensive effect of intracellular glutathione. Herein, we report a cathepsin B-controllable smart nanomedicine based on the structural and pharmacodynamic characteristics of artemisinin, which employed transferrin-peptide-modified mesoporous silica to codeliver artemisinin and buthionine-sulfoximine, a glutathione scavenger, into cancer cells. As a gatekeeper, the transferrin-peptide can not only target the cancer cells but also supply the extra ferrous iron to catalyze artemisinin to produce excessive ROS to kill cancer cells efficiently. Once the designed nanomedicine attack into lysosome of tumor cells, the cargos of nanomedicine can be released in the presence of cathepsin B to immediately activate self-amplification of oxidative stress by simultaneously elevating the levels of ROS and weakening the levels of glutathione. We anticipate that this rational design strategy provides innovative opportunities for artemisinin in the clinical application of cancer.
机译：虽然丰富的研究报告说，由于细胞内含有含有细胞内含铁离子和细胞内谷胱甘肽的细胞内含铁离子和防御性效果不足，葡萄原蛋白可以通过产生有毒反应性氧（ROS）来抑制癌细胞生长的抑制癌细胞生长。在此，基于氨化蛋白的结构和药物动力学特征报告一种组织蛋白酶B可控制的智能纳米胺，其使用转铁蛋白 - 肽改性的介氨酸和谷胱甘肽 - 磺酰胺，谷胱甘肽清除剂，谷胱甘肽清除剂进入癌细胞。作为守门人，转铁蛋白肽不仅可以靶向癌细胞，还可以提供额外的铁铁来催化甘氨酸，以产生过量的RO，以有效地杀死癌细胞。一旦被设计的纳米医生进入肿瘤细胞的溶酶体，纳米胺的尸体可以在组织蛋白酶B存在下释放，立即通过同时升高RO水平并削弱谷胱甘肽水平的氧化应激的自我扩增。我们预计这一合理的设计策略在癌症的临床应用中为青蒿素提供了创新机会。

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  • 来源
    《ACS applied materials & interfaces》 |2019年第33期|共8页
  • 作者

    Luo Yingping; Sun Xian; Huang Liwei; Yan Jin; Yu Bo-Yang; Tian Jiangwei;

  • 作者单位

    China Pharmaceut Univ Res Ctr Traceabil &

    Standardizat TCMs Sch Tradit Chinese Pharm State Key Lab Nat Med Jiangsu Key Lab TCM Evaluat Nanjing 211198 Jiangsu Peoples R China;

    China Pharmaceut Univ Res Ctr Traceabil &

    Standardizat TCMs Sch Tradit Chinese Pharm State Key Lab Nat Med Jiangsu Key Lab TCM Evaluat Nanjing 211198 Jiangsu Peoples R China;

    China Pharmaceut Univ Res Ctr Traceabil &

    Standardizat TCMs Sch Tradit Chinese Pharm State Key Lab Nat Med Jiangsu Key Lab TCM Evaluat Nanjing 211198 Jiangsu Peoples R China;

    China Pharmaceut Univ Res Ctr Traceabil &

    Standardizat TCMs Sch Tradit Chinese Pharm State Key Lab Nat Med Jiangsu Key Lab TCM Evaluat Nanjing 211198 Jiangsu Peoples R China;

    China Pharmaceut Univ Res Ctr Traceabil &

    Standardizat TCMs Sch Tradit Chinese Pharm State Key Lab Nat Med Jiangsu Key Lab TCM Evaluat Nanjing 211198 Jiangsu Peoples R China;

    China Pharmaceut Univ Res Ctr Traceabil &

    Standardizat TCMs Sch Tradit Chinese Pharm State Key Lab Nat Med Jiangsu Key Lab TCM Evaluat Nanjing 211198 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    cancer; artemisinin; mesoporous silica; nanomedicine; reactive oxygen species;

    机译：癌症;青蒿素;中孔二氧化硅;纳米胺;反应性氧;

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