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首页> 外文期刊>ACS applied materials & interfaces >pH-Responsive and Gemcitabine-Containing DNA Nanogel To Facilitate the Chemodrug Delivery
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pH-Responsive and Gemcitabine-Containing DNA Nanogel To Facilitate the Chemodrug Delivery

机译：pH-响应和含吉西众滨的DNA纳米凝胶，以促进化学树脂递送

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摘要

Herein, we construct a structure-switchable gemcitabine (Ge)-containing DNA nanogel that can respond to the intracellular acidic environment, subsequently facilitating the chemodrug release inside the cells. Based on the structural similarity between Ge and deoxycytidine (dC), dC nucleotides in the component DNA strands used for nanogel assembly are fully replaced by Ge during their synthesis. By changing the designed sequences, two Ge-containing Y-shaped motifs with different sticky ends are first assembled and then associated together to form nanogel by sticky-end hybridizations. In particular, one of the sticky-end sequences is arbitrarily designed to be rich of Ge and the other is designed to be partially complementary to the first Ge-rich sticky end. At the neutral or basic condition, the Ge-rich sticky ends hybridize with the partially complementary sticky ends on the second Y motifs, keeping the assembled nanogel stable. Upon being exposed to the acidic condition, Ge-rich sticky ends intend to form intramolecular i-motif-like quadruplex structures, resulting in the disassembly of the nanogel. On the one hand, the nanosized feature enables the Ge-containing nanogel with rapid cellular uptake behavior. On the other hand, the pH-responsive feature endows the rapid disassembly of the nanogel to facilitate the enzymatic drug release inside the cell, resulting in the enhanced anticancer activity of the DNA-based drug delivery system.
机译：在此，我们构建一种结构可切换的吉西他滨（GE） - 统一的DNA纳米凝胶，其可以响应细胞内酸性环境，随后促进细胞内的化学细胞释放。基于Ge和脱氧胞苷（DC）之间的结构相似性，用于纳米凝胶组件的组分DNA链中的DC核苷酸在合成期间被GE完全取代。通过改变设计的序列，首先组装两个具有不同粘性端部的含有不同粘性末端的GE的Y形丝绸。然后通过粘性杂交来组合形成纳米凝胶。特别地，其中一个粘性末端序列被任意设计为富含GE，另一个粘性件被设计成与第一GE丰富的粘性端部分互补。在中性或基本条件下，富含GE的粘性末端与第二Y基序的部分互补粘性末端杂交，保持组装的纳米凝胶稳定。在暴露于酸性条件后，富含含量的粘性末端旨在形成分子内I-MOTIF样的四边形结构，从而导致纳米凝胶的拆卸。一方面，纳米化特征使含GE的纳池具有快速的细胞摄取行为。另一方面，pH响应特征赋予纳米凝胶的快速拆卸以促进细胞内的酶毒释放，导致DNA的药物递送系统的增强抗癌活性。

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  • 来源
    《ACS applied materials & interfaces》 |2019年第44期|共9页
  • 作者

    Gaifang Pan; Quanbing Mou; Yuan Ma; Fei Ding; Jiao Zhang; Yuanyuan Guo; Xiangang Huang; Qifeng Li; Xinyuan Zhu; Chuan Zhang;

  • 作者单位

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

    Department of Paediatric Neurosurgery Xinhua Hospital Shanghai Jiao Tong University School of Medicine;

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

    School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    pH responsiveness; Ge-i-motif; gemcitabine; DNA nanogel; precise chemodrug delivery;

    机译：pH响应性;GE-I-MOTIF;吉西他滨;DNA Nanogel;精确的Chemodrug递送;

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