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首页> 外文期刊>ACS applied materials & interfaces >Pt-Decorated Boron Nitride Nanosheets as Artificial Nanozyme for Detection of Dopamine
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Pt-Decorated Boron Nitride Nanosheets as Artificial Nanozyme for Detection of Dopamine

机译：PT装饰的硼氮化物纳米片作为人工纳米酶检测多巴胺

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Over the past decade, nanosized metal oxides, metals, and bimetallic particles have been actively researched as enzyme mimetic nanomaterials. However, the common issues with individual nanoparticles (NPs) are stabilization, reproducibility, and blocking of active sites by surfactants. These problems promote further studies of composite materials, where NPs are spread on supports, such as graphene derivatives or dichalcogenide nanosheets. Another promising type of support for NPs is the few-layered hexagonal boron nitride (hBN). In this study, we develop surfactant-free nanocomposites containing Pt NPs dispersed on chemically modified hydrophilic hBN nanosheets (hBNNSs). Ascorbic acid was used as a reducing agent for the chemical reduction of the Pt salt in the presence of hBNNS aqueous colloid, resulting in Pt/hBNNS nanocomposites, which were thoroughly characterized with X-ray diffraction, transmission electron microscopy, dynamic light scattering, and X-ray photoelectron and infrared spectroscopies. Similar to graphene oxide binding the metal NPs more efficiently than pure graphene, hydrophilic hBNNSs well stabilize Pt NPs, with particle size down to around 8 nm. We further demonstrate for the first time that Pt/hBNNS nanocomposites exhibit peroxidase-like catalytic activity, accelerating the oxidation of the classical colorless peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) to its corresponding blue-colored oxidized product in the presence of H2O2. Kinetic and mechanism studies involving terephthalic acid and isopropanol as a fluorescent probe and an center dot OH radical scavenger, respectively, proved that Pt/hBNNSs assist H2O2 decomposition to active oxygen species (center dot OH), which are responsible for TMB oxidation. The Pt/hBNNS nanocomposite-assisted oxidation of TMB provides an effective platform for the colorimetric detection of dopamine, an important biomolecule. The presence of increased amounts of dopamine gradually inhibits the catalytic activity of Pt/hBNNSs for the oxidation of TMB by H2O2, thus enabling selective sensing of dopamine down to 0.76 mu M, even in the presence of common interfering molecules and on real blood serum samples. The present investigation on Pt/hBNNSs contributes to the knowledge of hBN-based nanocomposites and discovers their new usage as nanomaterials with good enzyme-mimicking activity and dopamine-sensing properties.
机译：在过去十年中，纳米化金属氧化物，金属和双金属颗粒被主动研究为酶模拟纳米材料。然而，通过表面活性剂是稳定性，再现性和活性位点的常见问题是稳定性，再现性和阻断活性位点。这些问题促进了对复合材料的进一步研究，其中NPS在载体上铺展，例如石墨烯衍生物或二硫代甲基纳米片。对NPS的另一种承诺类型的支持是少数层六边形氮化物（HBN）。在该研究中，我们在分散在化学改性的亲水性HBN纳米片（HBNNS）上分散在分散的Pt NPS的表面活性剂纳米复合材料。抗坏血酸用作在HBNNS水性胶体存在下进行PT盐的化学还原的还原剂，得到Pt / HBNNS纳米复合材料，其用X射线衍射，透射电子显微镜，动态光散射进行彻底表征。 X射线光电子和红外光谱。与纯石墨烯更有效地结合金属NPS的石墨烯氧化物，亲水性HBNNSS很好地稳定Pt NP，粒径下降至约8nm。我们进一步证明了第一次Pt / HBNN纳米复合材料表现出过氧化物酶样催化活性，将典型无色过氧化物酶基质3,3'，5,5'-四甲基苯胺（TMB）的氧化加速到其相应的蓝色氧化产物中在H 2 O 2的存在下。分别涉及对苯二甲酸和异丙醇作为荧光探针的动力学和机制研究证明，PT / HBNNSSS辅助H2O2分解对活性氧（中心点OH），其负责TMB氧化。 TMB的PT / HBNNS纳米复合材料辅助氧化为多巴胺的比色性检测提供了有效平台，这是一个重要的生物分子。多巴胺量的存在逐渐抑制Pt / hbnnss的催化活性通过H 2 O 2氧化TMB的氧化，从而使多巴胺的选择性感测到0.76μm，即使在共同的干扰分子和真正的血清样品上也是如此。本发明的对Pt / HBNNS的研究有助于了解基于HBN的纳米复合材料，并将其作为纳米材料的新用途发现，具有良好的酶 - 模拟活性和多巴胺感测性能。

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