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首页> 外文期刊>ACS applied materials & interfaces >High-Performance Worm-like Mn-Zn Ferrite Theranostic Nanoagents and the Application on Tumor Theranostics
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High-Performance Worm-like Mn-Zn Ferrite Theranostic Nanoagents and the Application on Tumor Theranostics

机译：高性能蠕虫样Mn-Zn铁氧体Theranostic Nanogents及肿瘤治疗型施用

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摘要

Previous reports from our team revealed the significant potential advantage of Mn-Zn ferrite nanoparticles (NPs) in magnetic resonance imaging (MRI), whereas anisotropic NPs reportedly increased the blood circulation time of nanocarriers. Thus, anisotropic Mn-Zn ferrite displayed a huge potential in cancer synchronous diagnosis and treatment, that is, enhanced MRI observation was performed simultaneously when drug-targeted delivery therapy was applied to the tumor. Here, we developed three shaped Mn-Zn ferrite (Mn0.63Zn0.37Fe2O4) MNPs used as cancer theranostic nanoagents and compared the effect of the three shaped MNPs on cancer theranostics. Compared to the monodisperse sphere MNPs (S-MNPs-PPR) and clustering MNPs (C-MNPs-PPR), worm-like Mn-Zn ferrite MNPs (W-MNPs-PPR) achieved better results in T-2-weighted MM and achieved more sustained drug release than S-MNPs-PPR and more complete drug release than C-MNPs-PPR in vitro. Additionally, polyethylene glycol (PEG) coating and RGD modification encouraged the three shaped MNPs to evade the recruitment of macrophages more easily and to target the integrin-enriched endothelial cells instead. Meanwhile, W-MNPs-PPR coupled with Paclitaxel (PTX) exhibited more delivery of PTX in the integrin-enriched cells than the other two shaped MNPs, and the content of PTX was far more than that of the wild-type Taxol control group. What is more, in vivo results demonstrated that PTX-coated W-MNPs-PPR not only gained good dual-mode imaging in the tumor (MRI and fluorescence images) but also achieved longer blood circulation time and more PTX-targeted delivery to the tumor, as well as more efficiency in tumor cell killing, which make the simultaneous diagnosis and treatment of tumors to be conducted. Therefore, our works further revealed the importance of the NP shape on its functionality and ultimately provided an alternative and efficient worm-like theranostic nanoagent for tumor theranostics.
机译：我们团队的先前报告揭示了Mn-Zn铁氧体纳米颗粒（NPS）在磁共振成像（MRI）中的显着潜力优势，而据报道，各向异性NP增加了纳米载体的血液循环时间。因此，各向异性Mn-Zn铁氧体在癌症同步诊断和治疗中显示出巨大的潜力，即当药物靶向递送治疗施用于肿瘤时同时进行增强的MRI观察。在这里，我们开发了三种形状的Mn-Zn铁素体（MN0.63Zn0.37Fe2O4）MnPS，用作癌症治疗纳米蛋白，并比较了三种形状MnP对癌症治疗癌症的影响。与单分散球体MNP（S-MNPS-PPR）和聚类MNPS（C-MNPS-PPR）相比，蠕虫样MN-Zn铁氧体MnPS（W-MNPS-PPR）在T-2加权MM中达到更好的结果：比S-MNPS-PPR更加持续释放药物释放，比体外比C-MNPS-PPR更完整的药物释放。另外，聚乙二醇（PEG）涂层和RGD改性促进了三种形状的MNP，以更容易地抑制巨噬细胞并靶向整合素的内皮细胞。同时，与紫杉醇（PTX）偶联的W-MNPS-PPR在整合蛋白富集的细胞中表现出比其他两个成形的MNP在整合蛋白的细胞中的更多递送，并且PTX的含量远远超过野生型紫杉醇对照组的含量。更重要的是，在体内结果表明，PTX涂覆的W-MNPS-PPR不仅在肿瘤（MRI和荧光图像）中不仅获得了良好的双模成像，而且还达到了血液循环时间和更高的PTX靶向递送给肿瘤以及更高的肿瘤细胞杀死效率，使得同时诊断和治疗肿瘤进行进行。因此，我们的作品进一步揭示了NP形状对其功能的重要性，并最终为肿瘤治疗方法提供了替代和有效的蠕虫样纳米型。

著录项

  • 来源
    《ACS applied materials & interfaces》 |2019年第33期|共13页
  • 作者

    Sun Yuxiang; Yan Caiyun; Xie Jun; Yan Dan; Hu Ke; Huang Shengxin; Liu Jianping; Zhang Yu; Gu Ning; Xiong Fei;

  • 作者单位

    Southeast Univ State Key Lab Bioelect Jiangsu Key Lab Biomat &

    Devices Sch Biol Sci &

    Med Engn Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ State Key Lab Bioelect Jiangsu Key Lab Biomat &

    Devices Sch Biol Sci &

    Med Engn Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ State Key Lab Bioelect Jiangsu Key Lab Biomat &

    Devices Sch Biol Sci &

    Med Engn Nanjing 210096 Jiangsu Peoples R China;

    Nanjing Med Univ Jiangsu Canc Hosp Dept Pharm Nanjing 210009 Jiangsu Peoples R China;

    Southeast Univ State Key Lab Bioelect Jiangsu Key Lab Biomat &

    Devices Sch Biol Sci &

    Med Engn Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ State Key Lab Bioelect Jiangsu Key Lab Biomat &

    Devices Sch Biol Sci &

    Med Engn Nanjing 210096 Jiangsu Peoples R China;

    China Pharmaceut Univ Dept Pharmaceut Nanjing 210009 Jiangsu Peoples R China;

    Southeast Univ State Key Lab Bioelect Jiangsu Key Lab Biomat &

    Devices Sch Biol Sci &

    Med Engn Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ State Key Lab Bioelect Jiangsu Key Lab Biomat &

    Devices Sch Biol Sci &

    Med Engn Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ State Key Lab Bioelect Jiangsu Key Lab Biomat &

    Devices Sch Biol Sci &

    Med Engn Nanjing 210096 Jiangsu Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    Mn-Zn ferrite; nanocarriers; nanotechnology for diagnosis and treatment; shape effects; tumor theranostics;

    机译：Mn-Zn铁氧体;纳米载波;纳米技术用于诊断和治疗;塑造效果;肿瘤Theranostics;

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