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首页> 外文期刊>ACS applied materials & interfaces >Microcapsules with Distinct Dual-Layer Shells and Their Applications for the Encapsulation, Preservation, and Slow Release of Hydrophilic Small Molecules
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Microcapsules with Distinct Dual-Layer Shells and Their Applications for the Encapsulation, Preservation, and Slow Release of Hydrophilic Small Molecules

机译：具有不同双层壳的微胶囊及其用于封装，保存和缓慢释放亲水性小分子的应用

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Microcapsules with two distinct layers of shells were fabricated using an approach combining microfluidics and photopolymerization. Unlike conventional microcapsules with a single shell, a fluorinated oil layer was introduced between the lumen and the outer polymer shell. The fluorinated oil layer significantly suppresses the leakage of the encapsulated ingredients in the lumen and consequently gives the microcapsules remarkable slow release capability for hydrophilic small molecule-based payloads, such as Rhodamine 6G. The release period of Rhodamine 6G can be up to 4 months when using a photocurable resin as the shell material, and the release of Rhodamine 6G can be regulated via the osmolality of the incubation solution for porous hydrogel microcapsules. Even under maximum hypotonic conditions, the release period of Rhodamine 6G in the hydrogel microcapsules is at least 10 days. The slow release capability can be significantly enhanced (6 weeks or longer) by increasing the thicknesses of the hydrogel shell and fluorinated oil layer.
机译：使用微流体和光聚合的方法制造具有两个不同层壳层的微胶囊。与具有单个壳体的常规微胶囊不同，在内腔和外聚合物壳之间引入氟化油层。氟化油层显着抑制了腔内包封成分的泄漏，因此使微胶囊具有显着的缓慢释放能力，用于亲水性的基于小分子的有效载荷，例如罗丹明6g。当使用可光固化树脂作为壳材料时，罗丹明6g的释放时期可以高达4个月，并且通过对多孔水凝胶微胶囊的培养溶液的渗透溶液来调节罗丹明6g的释放。即使在最大的低渗条件下，水凝胶微胶囊中罗丹明6g的释放时期也至少为10天。通过增加水凝胶壳和氟化油层的厚度，可以显着增强（6周或更长时间）的缓慢释放能力。

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