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首页> 外文期刊>ACS applied materials & interfaces >Facile Incorporation of 'Aggregation-Induced Emission'-Active Conjugated Polymer into Mesoporous Silica Hollow Nanospheres: Synthesis, Characterization, Photophysical Studies, and Application in Bioimaging
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Facile Incorporation of 'Aggregation-Induced Emission'-Active Conjugated Polymer into Mesoporous Silica Hollow Nanospheres: Synthesis, Characterization, Photophysical Studies, and Application in Bioimaging

机译：将“聚集诱导的发射” - 活性缀合聚合物的容纳掺入介孔二氧化硅中空纳米球中：合成，表征，光药研究和在生物体中的应用

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Typical aggregation-induced emission (AIE) luminogens tetraphenylethylene (TPE) and triphenylamine have been used to construct an AIE-active conjugated polymer, namely, poly(N,N-diphenyl-4-(4-(1,2,2-triphenylvinyl)styryl)aniline) (PTPA), which consist of D-pi-A architecture by Wittig polymerization. We fabricated mesoporous silica hollow nanospheres (MSHNs) which were encapsulated with the ME-active polymer for applications in cellular imaging. It exhibits a positive solvatochromism effect by increasing solvent polarity, supported by theoretical calculation using density functional theory. The structure of the monomers and polymer was confirmed by Fourier transform infrared, nuclear magnetic resonance, and high-resolution mass spectrometry techniques. Considering the advantage of high brightness in the fluorescence of PTPA, it was encapsulated into MSHNs by a noncovalent approach, and the surface was functionalized with an anti-EpCAM (antiepithelial cell adhesion molecule) aptamer through conjugation with gamma-glycidoxypropyltrimethoxysilane for targeting cancer cells specifically. The aptamer-functionalized Apt-MSHNs exhibited excellent biocompatibility with the liver cancer-Huh-7 cells used for this study and was efficiently internalized by these cells. Because EpCAM are overexpressed in multiple carcinomas, including liver cancer, these aptamer-conjugated AIE MSHNs are therefore good candidates for targeted cellular imaging applications.
机译：已经使用典型的聚集诱导的发射（AIE）发光聚苯基乙烯（TPE）和三苯胺用于构建AIE-活性缀合聚合物，即聚（N，N-二苯基-4-（4-（1,2,2-三苯基乙烯基） ）Styryl）苯胺）（PTPA）由Wittig聚合组成的D-PI-A架构。我们制造了介孔的二氧化硅中空纳米球（MSHNS），其用ME-活性聚合物包封，用于在细胞成像中的应用。它通过增加溶剂极性表现出积极的溶性溶性效果，通过使用密度函数理论的理论计算支持。通过傅里叶变换红外，核磁共振和高分辨率质谱技术确认单体和聚合物的结构。考虑到PTPA荧光中高亮度的优点，通过非共价方法将其包封在MSHN中，并且通过与γ-缩水氧基丙基三甲氧基硅烷缀合的抗EPCAM（抗癫痫细胞粘附分子）适体官能团用抗EPCAM（抗脑细胞粘附分子）官能团进行鉴定癌细胞。 Aptamer官能化APT-MSHN与用于该研究的肝癌-HUH-7细胞表现出优异的生物相容性，并被这些细胞有效内化。因为EPCAM在多个癌中过表达，包括肝癌，因此这些适体缀合的AIE MSHN是针对性细胞成像应用的良好候选者。

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