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首页> 外文期刊>ACS applied materials & interfaces >Syringe-Injectable, Self-Expandable, and Ultraconformable Magnetic Ultrathin Films
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Syringe-Injectable, Self-Expandable, and Ultraconformable Magnetic Ultrathin Films

机译：注射器可注射，可自涂，可自膨胀，磁性超薄薄膜

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Syringe-injectable biomaterials and medical devices are important as minimally invasive implants for diagnosis, therapy, and regenerative medicine. Free-standing polymeric nanosheets with a thickness less than 1 μm and a flexural rigidity less than 10~(–2) nN m are a promising platform of syringe-injectable, implantable devices that provide conformable and long-term stable adhesion to the target biological tissues for in situ delivery of therapeutic materials. Here, we developed free-standing ultrathin films (<1 μm thick) based on polyurethane-based shape-memory polymer (SMP) and magnetic nanoparticles (MNP), termed MNP-SMP nanosheets. With the temperature-mediated shape-memory effect of SMP, we overcome the limitation in the manipulation of the conventional polymer nanosheets. In particular, we demonstrated the following four capabilities using the 710 nm thick MNP-SMP nanosheet with the glass transition temperature (T _(g)) of 25 °C: (1) syringe-injectability through the medical needles, (2) self-expandability after ejection, (3) conformability and removability on the biological surfaces, and (4) guidability in an external magnetic field. The MNP-SMP nanosheets were readily interfaced with an additional layer of poly(lactic-co -glycolic acid) (PLGA) to extend their functionality as a carrier of molecular and cellular drugs. The MNP-SMP nanosheets will contribute to the development of advanced syringe-injectable medical devices as a platform to deliver drugs, sensors, cells, and engineered tissues to the specific site or lesion in the body for minimally invasive diagnosis and therapy.
机译：注射器可注射的生物材料和医疗器械是微创植入物的重要植入物，用于诊断，治疗和再生医学。厚度小于1μm的独立聚合物纳米片和小于10〜（-2）nn m的弯曲刚度是注射器可注射，可植入装置的有希望的平台，可提供对目标生物学的可适得和长期稳定的粘附性原位递送治疗材料的组织。在此，我们基于聚氨酯的形状记忆聚合物（SMP）和磁性纳米粒子（MNP）开发了独立的超薄薄膜（<1μm厚），称为MNP-SMP纳米晶片。随着SMP的温度介导的形状记忆效应，我们克服了常规聚合物纳米片的操纵中的限制。特别地，我们使用25℃的玻璃化转变温度（ T _（g））的710nm厚的MNP-SMP纳米片来证明了以下四种能力，通过医疗针的注射器可注射性（ 2）喷射后的自膨胀性，（3）在生物表面上的形式和可除载性，以及（4）外部磁场中的引导性。 MNP-SMP纳米片易于用另外的聚（乳酸 - 氯酸CO）（PLGA）层界面接合，以将其官能团延伸为分子和细胞药物的载体。 MNP-SMP纳米片将有助于开发先进的注射器可注射医疗器械作为将药物，传感器，细胞和工程组织递送到身体的特定部位或病变的平台，以微创诊断和治疗。

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