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首页> 外文期刊>ACS applied materials & interfaces >Hyperthemia-Promoted Cytosolic and Nuclear Delivery of Copper/Carbon Quantum Dot-Crosslinked Nanosheets: Multimodal Imaging-Guided Photothermal Cancer Therapy
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Hyperthemia-Promoted Cytosolic and Nuclear Delivery of Copper/Carbon Quantum Dot-Crosslinked Nanosheets: Multimodal Imaging-Guided Photothermal Cancer Therapy

机译：高温促进的铜/碳量子点交叉连接纳米片的细胞溶质和核递送：多峰显影引导的光热癌疗法

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摘要

Copper-containing nanomaterials have been applied in various fields because of their appealing physical, chemical, and biomedical properties/functions. Herein, for the first time, a facile, room-temperature, and one-pot method of simply mixing copper ions and sulfur-doped carbon dots (CDs) is developed for the synthesis of copper/carbon quantum dot (or CD)-crosslinked nanosheets (CuCD NSs). The thus-obtained CuCD NSs with the size of 20-30 nm had a high photothermal conversion efficiency of 41.3% and good photothermal stability. Especially, after coating with thiol-polyethylene glycol and fluorescent molecules, the resultant CuCD NSs could selectively target tumor tissues and realize multimodal (photoacoustic, photothermal, and fluorescence) imaging-guided cancer therapy. More importantly, our CuCD NSs exhibited laser-triggered cytosolic delivery, lysosomal escape, and nuclear-targeting properties, which greatly enhanced their therapeutic efficacy. The significantly enhanced tumor accumulation of CuCD NSs after in situ tumor-site laser irradiation was also observed in in vivo experiments. These in vitro and in vivo events occurring during the continuous laser irradiation have not been observed. Overall, this work develops a CD-assisted synthetic method of photothermal nanoagents for triple-modal imaging-guided phototherapy and deepens our understanding of the action mechanism of photothermal therapy, which will promote the development of nanomedicine and beyond.
机译：由于其吸引物理，化学和生物医学性质/功能，含铜纳米材料已经应用于各种领域。这里，对于简单地混合铜离子和硫掺杂的碳点（CD）的合成，首次进行简单地混合铜离子和硫掺杂的碳点（或CD）的合成的铜/碳量子点（或CD） - 克隆链接Nanosheets（CUCD NSS）。由此获得的尺寸为20-30nm的CUCD NSS具有41.3％的高光热转化效率和良好的光热稳定性。特别是，用硫醇 - 聚乙二醇和荧光分子涂覆后，所得CUCD NSS可以选择性地靶向肿瘤组织并实现成像导癌癌症治疗的多式式（光声，光热和荧光）。更重要的是，我们的CUCD NSS表现出激光触发的细胞溶质递送，溶酶体逸出和核靶向性质，这大大提高了其治疗效果。在体内实验中还观察到在原位肿瘤部位激光辐射后显着增强了CUCD NSS的肿瘤积累。在不连续激光照射期间发生的体外和体内事件尚未观察到。总体而言，这项工作开发了一种CD辅助合成方法的光热纳米蛋白，用于三重型成像引导的光疗法，深化我们对光热疗法动作机制的理解，这将促进纳米医生和超越的发展。

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