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Nanocapsules of Magnetic Au Self-Assembly for DNA Migration and Secondary Self-Assembly

机译:用于DNA迁移和二次自动组装的磁性AU自组装纳米胶囊

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摘要

To endow valuable responsiveness to self-assemblies of Au nanoparticles (Au NPs), the magnetic Au nanoparticles (Au NPs)/ C16H33(CH3)(3)N+ [CeCl3Br](-) (CTACe) mixtures were first prepared by using an emulsion self-assembly of a magnetic surfactant, C16H33(CH3)(3)N+ [CeCl3Br](-). A versatile morphology of self-assemblies of Au NPs could be controlled by the counterions in surfactants including [CeCl3Br], [FeCl3Br], and Br as well as solvent. In particular, the magnetic counterion, [CeCl3Br], can induce self-growth of Au NPs in an emulsion self assembly process due to the oxidability of [CeCl3Br]. It enhances the rigidity of Au NPs/CTACe scaffolds template compared with Au NPs/hexadecyltrimethylammonium bromide. [CeCI3Br](-) engaged Au NPs/CTACe with fascinating capability of conglutination and targeted migration of DNA (150 ymol/L) under a magnet field. The conglutination capability of the DNA molecules can increase to 39.8% by adopting the magnetic strategy when using Au NPs/CTACe as a magnetic booster. Au NPs/CTACe mixtures can ideally self-assemble to be scaffolds, providing abundant conjugation sites of surface charges. Magnetic Au NPs/CTACe can serve as a template scaffold to secondary self-assemble with DNA (40 mmol/L) outside, producing smooth-faced and hollow DNA nanocapsules. We believe that the creative Au NPs/ CTACe/DNA nanocapsules will extend the biological application field of Au NPs assemblies.
机译:为了赋予Au纳米颗粒(Au nps)的自组装的宝贵反应,首先通过使用乳液制备磁性Au纳米颗粒(Au nps)/ C16H33(CH 3)(3)N + [CECL3BR]( - )(CTACE)混合物磁性表面活性剂,C16H33(CH3)(3)N + [CECL3BR]( - )的自组装。可以通过包括[CECL3BR],[FECL3BR]和BR以及溶剂的表面活性剂中的抗衡离子来控制Au NPS的多功能形态。特别地,磁抗抵抗(CECL3BR)可​​以在乳液自组装过程中诱导Au NP的自我生长,这是由于[CECL3BR]的氧化性的乳液自组装过程。它增强了Au NPS / CTACE支架模板的刚性与Au nps / hexadecyltrimethylammium溴化物相比。 [Ceci3br]( - )接合Au NPS / CTACE,具有磁场下DNA(150 ymol / L)的粘合性和靶向迁移的迷人能力。当使用Au NPS / CTACE作为磁力助力器时采用磁策略,DNA分子的孔化能力可以增加至39.8%。 Au NPS / CTACE混合物可以理想地自组装为支架,提供丰富的表面电荷的共轭部位。磁性AU NPS / CTACE可以用作外部DNA(40mmol / L)的二次自组装的模板支架,产生光滑的脸部和中空DNA纳米胶囊。我们认为,创意AU NPS / CTACE / DNA纳米胶囊将延长AU NPS组件的生物应用领域。

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