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首页> 外文期刊>ACS applied materials & interfaces >Flexible Amoxicillin-Grafted Bacterial Cellulose Sponges for Wound Dressing: In Vitro and in Vivo Evaluation
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Flexible Amoxicillin-Grafted Bacterial Cellulose Sponges for Wound Dressing: In Vitro and in Vivo Evaluation

机译：柔性阿莫西林 - 嫁接细菌纤维素海绵伤口敷料：体外和体内评价

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摘要

In this study, we report the design and fabrication of a novel biocompatible sponge with excellent antibacterial property, making it a promising material for wound dressings. The sponge is formed by grafting amoxicillin onto regenerated bacterial cellulose (RBC). It was observed that the grafted RBC could enhance the antibacterial activity against fungus, Gram-negative, and Gram-positive bacteria. The morphology of strains treated with the grafted RBC and fluorescent stain results further demonstrated the antibacterial ability of the fabricated sponge. Moreover, a cytocompatibility test evaluated in vitro and in vivo illustrates the nontoxicity of the prepared sponge. More importantly, the wound infection model reveals that this sponge can accelerate the wound healing in vivo. This work indicates the novel sponge has the huge potential in wound dressing application for clinical use.
机译：在这项研究中，我们报告了一种具有优异抗菌性的新型生物相容性海绵的设计和制造，使其成为伤口敷料的有希望的材料。 通过将阿莫西林嫁接到再生细菌纤维素（RBC）上形成海绵。 观察到接枝的RBC可以增强针对真菌，革兰氏阴性和革兰氏阳性细菌的抗菌活性。 用接枝的RBC和荧光染色结果处理的菌株的形态进一步证明了制造的海绵的抗菌能力。 此外，在体外和体内评估的细胞组合试验说明了制备的海绵的无毒性。 更重要的是，伤口感染模型表明，该海绵可以加速体内伤口愈合。 这项工作表明新的海绵有伤口敷料应用巨大潜力用于临床用途。

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  • 作者

    Ye Shan; Jiang Lei; Wu Jimin; Su Chen; Huang Chaobo; Liu Xiufeng; Shao Wei;

  • 作者单位

    Nanjing Forestry Univ Coll Chem Engn Nanjing 210037 Jiangsu Peoples R China;

    Nanjing Forestry Univ Coll Chem Engn Nanjing 210037 Jiangsu Peoples R China;

    Nanjing Forestry Univ Coll Chem Engn Nanjing 210037 Jiangsu Peoples R China;

    Nanjing Forestry Univ Coll Chem Engn Nanjing 210037 Jiangsu Peoples R China;

    Nanjing Forestry Univ Coll Chem Engn Nanjing 210037 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Tradit Chinese Pharm State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    Nanjing Forestry Univ Coll Chem Engn Nanjing 210037 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    bacterial cellulose; sponge; antibacterial; cytocompatibility; wound dressing;

    机译：细菌纤维素;海绵;抗菌;细胞组分;伤口敷料;

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