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首页> 外文期刊>ACS applied materials & interfaces >Biodegradable Neuro-Compatible Peptide Hydrogel Promotes Neurite Outgrowth, Shows Significant Neuroprotection, and Delivers Anti-Alzheimer Drug
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Biodegradable Neuro-Compatible Peptide Hydrogel Promotes Neurite Outgrowth, Shows Significant Neuroprotection, and Delivers Anti-Alzheimer Drug

机译：可生物降解的神经相容性肽水凝胶促进神经突的过度，显示出显着的神经保护作用，并提供抗阿尔茨海默药物

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摘要

A novel neuro-compatible peptide-based hydrogel has been designed and developed, which contains microtubule stabilizing and neuroprotective short peptide. This hydrogel shows strong three-dimensional cross-linked fibrillary networks, which can capture water molecules. Interestingly, this hydrogel serves as excellent biocompatible soft material for 2D and 3D (neurosphere) neuron cell culture and provides stability of key cytoskeleton filaments such as microtubule and actin. Remarkably, it was observed that this hydrogel slowly enzymatically degrades and releases neuroprotective peptide, which promotes neurite outgrowth of neuron cell as well as exhibits excellent neuroprotection against anti-NGF-induced toxicity in neuron cells. Further, it can encapsulate anti-Alzheimer and anticancer hydrophobic drug curcumin, releases slowly, and inhibits significantly the growth of a 3D spheroid of neuron cancer cells. Thus, this novel neuroprotective hydrogel can be used for both neuronal cell transplantation for repairing brain damage as well as a delivery vehicle for neuroprotective agents, anti-Alzheimer, and anticancer molecules.
机译：设计和开发了一种新型神经相容性肽的水凝胶，其含有微管稳定和神经保护短肽。该水凝胶显示出强大的三维交联纤维网络，可以捕获水分子。有趣的是，该水凝胶作为2D和3D（神经圈）神经元细胞培养的优异的生物相容性软材料，并提供关键细胞骨架长丝如微管和肌动蛋白的稳定性。值得注意的是，观察到该水凝胶缓慢酶促降解并释放神经保护肽，其促进神经元细胞的神经突生长，以及在神经元细胞中表现出优异的抗NGF诱导的毒性。此外，它可以包封抗阿尔茨海默和抗癌疏水药物姜黄素，缓慢释放，并显着抑制神经元癌细胞的3D球体的生长。因此，该新型神经保护水凝胶可用于神经元细胞移植，用于修复脑损伤以及用于神经保护剂，抗阿尔茨海默和抗癌分子的递送载体。

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