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首页> 外文期刊>ACS applied materials & interfaces >Preparation, Characterization, and Mechanism for Biodegradable and Biocompatible Polyurethane Shape Memory Elastomers
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Preparation, Characterization, and Mechanism for Biodegradable and Biocompatible Polyurethane Shape Memory Elastomers

机译：可生物降解和生物相容性聚氨酯形状记忆弹性体的制备，表征和机理

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摘要

Thermally induced shape memory is an attractive feature of certain functional materials. Among the shape memory polymers, shape memory elastomers (SMEs) especially those with biodegradability have great potential in the biomedical field. In this study, we prepared waterborne biodegradable polyurethane SME based on poly(e-caprolactone) (PCL) oligodiol and poly(L-lactic acid) (PLLA) oligodiol as the mixed soft segments. The ratio of the soft segments in polyurethanes was optimized for shape memory behavior. The thermally induced shape memory mechanism of the series of polyurethanes was clarified using differential scanning calorimeter (DSC), X-ray diffraction (XRD), and small -angle X-ray scattering (SAXS). In particular, the in situ SAXS measurements combined with shape deformation processes were employed to examine the stretch -induced (oriented) crystalline structure of the polyurethanes and to elucidate the unique mechanism for shape memory properties. The polyurethane with optimized PLLA crystalline segments showed a diamond -shape two-dimensional SAXS pattern after being stretched, which gave rise to better shape fixing and shape recovery. The shape Memory behavior was further tested in 37 degrees C water. The biodegradable polyurethane comprising 38 wt % PCL segments and 25 wt % PLLA segments and synthesized at a relatively lower temperature by the waterborne procedure showed similar to 100% shape recovery in 37 degrees C water. The biodegradable polyurethane SME also demonstrated good endothelial cell Viability as well as low platelet adhesion/activation. We conclude that the waterborne biodegradable polyurethane SME possesses a unique thermally induced shape memory mechanism and may have potential applications in making shape memory biodegradable stents or scaffolds.
机译：热诱导形状存储器是某些功能材料的有吸引力的特征。在形状记忆聚合物中，形状记忆弹性体（SME）尤其是具有生物降解性的那些具有巨大的生物医学领域的潜力。在这项研究中，我们制备了基于聚（E-己内酯）（PCL）的低摩托二醇和聚（L-乳酸）（PLLA）脱摩托醇作为混合软链脱层的水性可生物降解的聚氨酯中小型。优化聚氨酯中的软段的比例以形成形状记忆行为。使用差示扫描量热仪（DSC），X射线衍射（XRD）和小--Angle X射线散射（SAXS）阐明了该系列聚氨酯的热诱导的形状记忆机构。特别地，使用与形状变形过程相结合的原位淋巴测量以检查聚氨酯的拉伸诱导的（定向的）结晶结构，并阐明形状记忆性能的独特机制。具有优化PLLA结晶段的聚氨酯在拉伸后显示了金刚石 - 形状的二维萨克斯图案，其产生更好的形状固定和形状回收。形状存储器行为在37℃水中进一步测试。将可生物降解的聚氨酯包含38wt％PCL段和25wt％PLLA段，并通过水性程序在相对较低的温度下合成类似于37℃水中的100％形状回收。可生物降解的聚氨酯中小企业还证明了良好的内皮细胞活力以及低血小板粘附/活化。我们得出结论，水性可生物降解的聚氨酯中小企业具有独特的热诱导的形状记忆机构，并且可以具有制造形状记忆可生物降解支架或支架的潜在应用。

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