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首页> 外文期刊>ACS applied materials & interfaces >Fabrication of Nanostructured Mesoporous Germanium for Application in Laser Desorption Ionization Mass Spectrometry
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Fabrication of Nanostructured Mesoporous Germanium for Application in Laser Desorption Ionization Mass Spectrometry

机译：纳米结构介孔锗的制备在激光解吸电离质谱中应用

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Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a high-throughput analytical technique ideally suited for small-molecule detection from different bodily fluids (e.g., saliva, urine, and blood plasma). Many SALDI-MS substrates require complex fabrication processes and further surface modifications. Furthermore, some substrates show instability upon exposure to ambient conditions and need to be kept under special inert conditions. We have successfully optimized mesoporous germanium (meso-pGe) using bipolar electrochemical etching and efficiently applied meso-pGe as a SALDI-MS substrate for the detection of illicit drugs such as in the context of workplace, roadside, and antiaddictive drug compliance. Argon plasma treatment improved the meso-pGe efficiency as a SALDI-MS substrate and eliminated the need for surface functionalization. The resulting substrate showed a precise surface geometry tuning by altering the etching parameters, and an outstanding performance for illicit drug detection with a limit of detection in Milli-Q water of 1.7 ng/mL and in spiked saliva as low as 5.3 ng/mL for cocaine. The meso-pGe substrate had a demonstrated stability over 56 days stored in ambient conditions. This proof-of-principle study demonstrates that meso-pGe can be reproducibly fabricated and applied as an analytical SALDI-MS substrate which opens the door for further analytical and forensic high-throughput applications.
机译：表面辅助激光解吸/电离质谱（SALDI-MS）是一种高通量分析技术，理想地适用于来自不同体液（例如唾液，尿液和血浆）的小分子检测。许多SALDI-MS基材需要复杂的制造工艺和进一步的表面修饰。此外，一些基板在暴露于环境条件时显示不稳定性，并且需要在特殊的惰性条件下保持。我们已经成功地使用双极电化学蚀刻优化了介孔锗（Meso-PGE），并有效地施加了Meso-PGE作为SALDI-MS衬底，用于检测非法药物，例如在工作场所，路边和抗真证药物依从性的背景下。氩等离子体处理改善了Meso-PGE效率作为SALDI-MS底物，并消除了表面官能化的需要。通过改变蚀刻参数，得到精确的表面几何调整，以及用于非法药物检测的出色性能，其在1.7ng / ml的毫Q水中的检测限，并且在尖刺的唾液中低至5.3ng / ml可卡因。 Meso-PGE衬底的稳定性在环境条件下储存超过56天。这种原则上的研究证明，Meso-PGE可以可重复制造并施加为分析SALDI-MS衬底，该分析SALDI-MS衬底，用于为进一步的分析和法医高通量应用打开门。

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