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首页> 外文期刊>ACS applied materials & interfaces >Tumor Microenvironment Modulation by Cyclopamine Improved Photothermal Therapy of Biomimetic Gold Nanorods for Pancreatic Ductal Adenocarcinomas
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Tumor Microenvironment Modulation by Cyclopamine Improved Photothermal Therapy of Biomimetic Gold Nanorods for Pancreatic Ductal Adenocarcinomas

机译：肿瘤微环境调制通过环丙胺改善胰腺导管腺癌仿真金纳米棒的光热疗

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摘要

Due to the rich stroma content and poor blood perfusion, pancreatic ductal adenocarcinoma (PDA) is a tough cancer that can hardly be effectively treated by chemotherapeutic drugs. Tumor microenvironment modulation or advanced design of nanomedicine to achieve better therapeutic benefits for PDA treatment was widely advocated by many reviews. In the present study, a new photothermal therapy strategy of PDA was developed by combination of tumor microenvironment modulation and advanced design of biomimetic gold nanorods. On one hand, biomimetic gold nanorods were developed by coating gold nanorods (GNRs) with erythrocyte membrane (MGNRs). It was shown that MGNRs exhibited significantly higher colloidal stability in vitro, stronger photothermal therapeutic efficacy in vitro, and longer circulation in vivo than GNRs. On the other hand, tumor microenvironment modulation by cyclopamine treatment successfully disrupted the extracellular matrix of PDA and improved tumor blood perfusion. Moreover, cyclopamine treatment significantly increased the accumulation of MGNRs in tumors by 1.8-fold and therefore produced higher photothermal efficiency in vivo than the control group. Finally, cyclopamine treatment combined with photothermal MGNRs achieved the most significant shrinkage of Capan-2 tumor xenografts among all the treatment groups. Therefore, with the integrated advantages of tumor microenvironment regulation and long-circulation biomimetic MGNRs, effective photothermal therapy of PDA was achieved. In general, this new strategy of combining tumor microenvironment modulation and advanced design of biomimetic nanoparticles might have great potential in PDA therapy.
机译：由于具有丰富的基质含量和血液灌注不良，胰腺导管腺癌（PDA）是一种艰难的癌症，可以通过化学治疗药物很难有效处理。肿瘤微环境调制或纳米医生的先进设计，以实现PDA治疗的更好治疗益处被许多评论得到了广泛主张的倡导。在本研究中，通过肿瘤微环境调制和仿生金纳米棒的先进设计，开发了一种新的PDA的光热疗策略。一方面，通过用红细胞膜（MgNR）涂覆金纳米棒（GNRS）开发仿生金纳米棒。结果表明，MGNR在体外具有显着更高的胶体稳定性，在体外具有更强的光热治疗效果，并且比GNR在体内更长的循环。另一方面，通过环丙氨酸处理的肿瘤微环境调节成功破坏了PDA的细胞外基质和改善的肿瘤血液灌注。此外，环丙氨酸处理显着增加了1.8倍的肿瘤中MGNR的积累，因此在体内产生比对照组更高的光热效率。最后，与光热MgNR结合的环丙胺处理在所有治疗组中均达到Capan-2肿瘤异种移植物最显着的收缩。因此，随着肿瘤微环境调节和长循环生物摩擦MGNR的集成优势，实现了PDA的有效光热疗。通常，这种结合肿瘤微环境调制和仿生纳米颗粒的先进设计的新策略可能具有很大的PDA疗法潜力。

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  • 来源
    《ACS applied materials & interfaces》 |2017年第37期|共12页
  • 作者

    Jiang Ting; Zhang Bo; Shen Shun; Tuo Yanyan; Luo Zimiao; Hu Yu; Pang Zhiqing; Jiang Xinguo;

  • 作者单位

    Huazhong Univ Sci &

    Technol Inst Hematol Union Hosp Tongji Med Coll Wuhan 430022 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Inst Hematol Union Hosp Tongji Med Coll Wuhan 430022 Hubei Peoples R China;

    Fudan Univ Sch Pharm Key Lab Smart Drug Delivery Minist Educ 826 Zhangheng Rd Shanghai 201203 Peoples R China;

    Fudan Univ Sch Pharm Key Lab Smart Drug Delivery Minist Educ 826 Zhangheng Rd Shanghai 201203 Peoples R China;

    Fudan Univ Sch Pharm Key Lab Smart Drug Delivery Minist Educ 826 Zhangheng Rd Shanghai 201203 Peoples R China;

    Huazhong Univ Sci &

    Technol Inst Hematol Union Hosp Tongji Med Coll Wuhan 430022 Hubei Peoples R China;

    Fudan Univ Sch Pharm Key Lab Smart Drug Delivery Minist Educ 826 Zhangheng Rd Shanghai 201203 Peoples R China;

    Fudan Univ Sch Pharm Key Lab Smart Drug Delivery Minist Educ 826 Zhangheng Rd Shanghai 201203 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    tumor microenvironment modulation; cyclopamine; biomimetic gold nanorods; erythrocyte membrane; photothermal therapy; pancreatic ductal adenocarcinomas;

    机译：肿瘤微环境调制;环丙胺;生物摩擦金纳米棒;红细胞膜;光热疗法;胰腺导管腺癌;

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