• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Reconstitution of autophagy ameliorates vascular function and arterial stiffening in spontaneously hypertensive rats
【24h】

Reconstitution of autophagy ameliorates vascular function and arterial stiffening in spontaneously hypertensive rats

机译：自噬重建改善了自发性高血压大鼠的血管功能和动脉溶液

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Insufficient autophagy has been proposed as a mechanism of cellular aging, as this leads to the accumulation of dysfunctional macromol-ecules and organelles. Premature vascular aging occurs in hypertension. In fact, many factors that contribute to the deterioration of vascular function as we age are accelerated in clinical and experimental hypertension. Previously, we have reported decreased autophagy in arteries from spontaneously hypertensive rats (SHRs); however, the effects of restoring autophagic activity on blood pressure and vascular function are currently unknown. We hypothesized that reconstitution of arterial autophagy in SHRs would decrease blood pressure and improve endothelium-dependent relaxation. We treated 14- to 18-wk-old Wistar rats (n = 7 vehicle and n = 8 Irehalose) and SHRs (n = 7/group) with autophagy activator trehalose (2% in drinking water) for 28 days. Blood pressure was measured by radiotelemetry, and vascular function and structure were measured in isolated mesenteric resistance arteries (MRAs) using wire and pressure myographs, respectively. Treatment with trehalose had no effect on blood pressure in SHRs; however, isolated MRAs presented enhanced relaxation to acetylcholine, in a cyclooxygenase- and reactive oxygen species-dependent manner. Similarly, trehalose treatment shifted the relaxation to the Rho kinase (ROCK) inhibitor Y-27632 to the right, indicating reduced ROCK activity. Finally, trehalose treatment decreased arterial stiffness as indicated by the slope of the stress-strain curve. Overall these data indicate that reconstitution of arterial au-lophagy in SHRs improves endothelial and vascular smooth muscle function, which could synergize to prevent stiffening. As a result, restoration of autophagic activity could be a novel therapeutic for premature vascular aging in hypertension.
机译：已经提出了不充分的自噬作为细胞衰老机制，因为这导致功能障碍大溴酚和细胞器的积累。过早血管老化发生高血压。事实上，随着我们年龄的增长的血管功能恶化的许多因素在临床和实验性高血压中加速了血管功能的恶化。以前，我们报道了从自发性高血压大鼠（SHR）的动脉中的自噬减少;然而，恢复自噬活性对血压和血管功能的影响目前未知。我们假设在SHRS中的动脉自噬重构会降低血压并改善内皮依赖性的放松。我们用自噬活性剂海藻糖（饮用水中2％）治疗14-至18周龄Wistar大鼠（n = 7载体和N = 8次）和shrs（n = 7 /组）28天。通过无线电测定测量血压，并分别使用电线和压力逼测测量血管功能和结构，使用电线和压力逼测测量。用海藻糖处理对SHRS中的血压没有影响;然而，孤立的MRAS以环氧酶 - 和反应性氧物种依赖性方式提高对乙酰胆碱的增强弛豫。类似地，海藻糖治疗将弛豫转移到rhO激酶（岩）抑制剂Y-27632向右，表明岩石活性降低。最后，海藻糖处理如应力 - 应变曲线的斜率所示降低了动脉僵硬度。总体而言，这些数据表明，在SHRS中的动脉Au-leophagy重建改善内皮和血管平滑肌功能，这可能改变以防止加强。结果，恢复自噬活性可能是高血压过早血管老化的新型治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号