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首页> 外文期刊>American Journal of Physiology >Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity
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Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity

机译：运动刺激有益的适应，以减少多柔枯蛋白诱导的细胞毒性

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摘要

Doxorubicin (DOX) is a highly effective antitumor agent used for the treatment of a wide range of cancers. Unfortunately, DOX treatment results in cytotoxic side effects due to its accumulation within off-target tissues. DOX-induced cellular toxicity occurs as a result of increased oxidative damage, resulting in apoptosis and cell death. While there is no standard-of-care practice to prevent DOX-induced toxicity to healthy organs, exercise has been shown to prevent cellular dysfunction when combined with DOX chemotherapy. Endurance exercise stimulates numerous biochemical adaptations that promote a healthy phenotype in several vulnerable tissues without affecting the antineoplastic properties of DOX. Therefore, for the development of an effective strategy to combat the pathological effects of DOX, it is important to determine the appropriate exercise regimen to prescribe to cancer patients receiving DOX therapy and to understand the mechanisms responsible for exercise-induced protection against DOX toxicity to noncancer cells. This review summarizes the cytotoxic effects of DOX on the heart, skeletal muscle, liver, and kidneys and discusses the current understanding of the clinical benefits of regular physical activity and the potential mechanisms mediating the positive effects of exercise on each organ system.
机译：多柔比星（DOX）是一种高效的抗肿瘤剂，用于治疗各种癌症。不幸的是，DOX治疗导致细胞毒性副作用由于其在偏移组织内积聚。随着氧化损伤的增加，DOX诱导的细胞毒性发生，导致细胞凋亡和细胞死亡。虽然没有防止Dox诱导的健康器官毒性的标准保健做法，但已经显示出锻炼以防止在与DOX化疗结合时进行细胞功能障碍。耐力运动刺激许多生化适应，促进若干弱势组织中健康表型，而不会影响DOX的抗肿瘤性质。因此，为了开发有效策略来打击DOX的病理效果，确定适当的运动方案，规定接受DOX治疗的癌症患者，并了解负责运动诱导的毒性对非癌症的毒性的机制细胞。本综述总结了DOX对心脏，骨骼肌，肝脏和肾脏的细胞毒性作用，并探讨了目前对常规体育活动的临床益处的理解及介导运动对每个器官系统的潜在机制。

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