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首页> 外文期刊>American Journal of Physiology >Slc26a6 is an apical membrane anion exchanger that drives HCO_3 -dependent fluid secretion in murine pancreatic acinar cells
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Slc26a6 is an apical membrane anion exchanger that drives HCO_3 -dependent fluid secretion in murine pancreatic acinar cells

机译：SLC26A6是一种顶端膜阴离子交换器，其驱动HCO_3依赖性液体分泌在鼠胰腺缩醛细胞中

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摘要

The nonselective anion exchanger Slc26a6, also known as putative anion transporter 1 and chloride/formate exchanger, is thought to play a major role in HCO_3~ transport in exocrine glands. In this study, Slc26a6 null mice were used to explore the function of Slc26a6 in the exocrine pancreas. Slc26a6 primarily localized to the apical membrane of pancreatic exocrine acinar cells. The volume of stimulated juice secretion by the ex vivo pancreas was significantly reduced -35% in Slc26a6~/~ mice, but no changes occurred in the gross structure or gland weights of Slc26a6 null mice. The secretion of pancreatic juice by SIc26a6+/+ mice was dependent on HCO_3~ while, in contrast, fluid secretion by Slc26a6~/~ mice was independent of HCO_3~, suggesting that Slc26a6 mediates the HCO_3~-dependent component of fluid secretion. Consistent with these observations, disruption of S1c26a6 also significantly reduced HCO_3~ secretion by the pancreas -35%. Taken together, these results demonstrate that the apical Slc26a6 anion exchanger in acinar cells is involved in HCO_3~ -dependent fluid secretion but that another major HCO_3~-independent pathway is the primary driver of the fluid secretion process in the mouse pancreas.
机译：尚称为推定阴离子转运蛋白1和氯化物/甲酸甲酸交换器的非选择性阴离子交换器SLC26A6被认为在外分泌腺中的HCO_3〜运输中发挥重要作用。在该研究中，SLC26A6含氟小鼠用于探索外分胰腺中SLC26A6的功能。 SLC26a6主要定位于胰腺外分泌缩醛细胞的顶端膜。在SLC26A6〜/〜小鼠中，前体内胰腺的受刺激汁分泌的体积显着降低-35％，但SLC26A6零小鼠的总结构或腺体重量没有发生变化。 SiC26a6 + / +小鼠胰汁的分泌依赖于HCO_3〜，相比之下，SLC26A6〜/〜小鼠的流体分泌与HCO_3〜差异，表明SLC26A6介导流体分泌的HCO_3〜依赖性组分。与这些观察结果一致，S1C26A6的破坏也通过胰腺-35％显着降低了HCO_3〜分泌。总之，这些结果表明，丙氨酸细胞中的顶端SLC26A6阴离子交换剂参与HCO_3〜依赖性流体分泌，但另一个主要的HCO_3〜依赖性途径是小鼠胰腺中流体分泌过程的主要驱动器。

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