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首页> 外文期刊>American Journal of Physiology >An in silico simulation of flow-mediated dilation reveals that blood pressure and other factors may influence the response independent of endothelial function.
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An in silico simulation of flow-mediated dilation reveals that blood pressure and other factors may influence the response independent of endothelial function.

机译：流动介导扩张的硅模拟显示，血压和其他因素可能影响与内皮功能无关的反应。

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摘要

Endothelial dysfunction is thought to underpin atherosclerotic cardiovascular disease. The most widely used in vivo test of endothelial function is flow-mediated dilation (FMD). However, the results of FMD may be subject to some confounding factors that are not fully understood. We investigated potential biophysical confounding factors that could cause a disassociation between FMD and true endothelial cell shear stress response (the release of endothelium-dependent relaxing factors in response to wall shear stress). Arterial hemodynamics during FMD was simulated using a novel computational modeling approach. The model included an endothelial response function relating changes in wall shear stress to changes in local vascular stiffness in the arm arteries and accounted for vascular stiffening with increasing blood pressure. The hemodynamic effects of cuff inflation and deflation were modeled by prescribing intraluminal arterial pressure changes and peripheral vasodilation. Evolution of arterial diameter and flow velocity during FMD was assessed by comparison against in vivo data. Our model revealed that vasoconstriction occurring immediately after cuff deflation is independent of endothelial response function and entirely caused by the change in transmural pressure along conduit arteries. Moreover, for the same endothelial response function model, FMD values increased exponentially with increasing peak flow velocity, decreased linearly with increasing arterial stiffness at a rate of 0.95%/MPa, and increased linearly with increasing central blood pressure at a rate of 0.22%/mmHg. Dependence of FMD on confounding factors, such as arterial stiffness and blood pressure, suggests that the current FMD test may not reflect the true endothelial cell response.
机译：内皮功能障碍被认为是在动脉粥样硬化的心血管疾病中。最广泛用于内皮函数的体内试验是流动介导的扩张（FMD）。然而，FMD的结果可能受到一些不完全理解的混杂因素。我们调查了可能导致FMD和真正的内皮细胞剪切应力响应之间脱离的潜在的生物物理混淆因子（响应于壁剪切应力的内皮依赖性放松因子的释放）。使用一种新颖的计算建模方法模拟FMD期间的动脉血流动力学。该模型包括内皮响应函数，其侧壁剪切应力变化与臂动脉中局部血管刚度的变化变化，并占血压增加的血管加强。通过规定腔内动脉压力变化和外周血管血管血管膨胀和放气的血流动力学效应。通过对体内数据进行评估，评估FMD期间动脉直径和流速的演变。我们的模型揭示了沟槽通货紧缩后立即发生的血管收缩，与内皮响应函数无关，并且完全由沿导管动脉的透气压力变化引起的。此外，对于相同的内皮响应函数模型，FMD值随着峰值流速的增加而增加，随着0.95％/ MPa的速率而增加，随着动脉刚度的增加，随着0.22％的速率而增加，随着中央血压的增加而增加。 mmhg。 FMD对混淆因子的依赖性，例如动脉僵硬和血压，表明目前的FMD测试可能不反映真正的内皮细胞反应。

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