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首页> 外文期刊>American Journal of Physiology >Rats are protected from the stress of chronic pressure overload compared with mice.
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Rats are protected from the stress of chronic pressure overload compared with mice.

机译：与小鼠相比，保护大鼠免受慢性压力过载的应力。

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摘要

The goal of this investigation was to compare the effects of chronic (4 wk) transverse aortic constriction (TAC) in Sprague-Dawley rats and C57BL/6J mice. TAC, after 1 day, induced similar left ventricular (LV) pressure gradients in both rats (n = 7) and mice (n = 7) (113 ± 5.4 vs. 103 ±11.5 mmHg), and after 4 wk, the percent increase in LV hypertrophy, as reflected by LV/tibial length (51% vs 49%), was similar in rats (n = 12) and mice (n = 12). After 4 wk of TAC, LV systolic and diastolic function were preserved in TAC rats. In contrast, in TAC mice, LV ejection fraction decreased by 31% compared with sham, along with increases in LV end-diastolic pressure (153%) and LV systolic wall stress (86%). Angiogenesis, as reflected by Ki67 staining of capillaries, increased more in rats (n = 6) than in mice (n = 6; 10 ± 2 vs. 6 ± 1 Ki67-positive cells/field). Myocardial blood flow fell by 55% and coronary reserve by 28% in mice with TAC (n = 4), but they were preserved in rats (n = 4). Myogenesis, as reflected by c-kit-positive myocytes staining positively for troponin I, is another mechanism that can confer protection after TAC. However, the c-kit-positive cells in rats with TAC were all negative for troponin I, indicating the absence of myogenesis. Thus, rats showed relative tolerance to severe pressure overload compared with mice, with mechanisms involving angiogenesis but not myogenesis.
机译：该研究的目的是比较Sprague-Dawley大鼠和C57BL / 6J小鼠中慢性（4WK）横向主动脉收缩（TAC）的影响。 TAC在1天后，在大鼠（n = 7）和小鼠（n = 7）（113±5.4与103±11.5mmHg）中诱导相似的左心室（LV）压力梯度（113±5.4毫米），并且在4周后，增加百分比在LV肥大中，由LV /胫骨长（51％Vs 49％）反射，在大鼠（n = 12）和小鼠（n = 12）中相似。经过4周的TAC，在TAC大鼠中保留了LV收缩函数和舒张功能。相反，在TAC小鼠中，与假的LV喷射部分减少了31％，随着LV端舒张压（153％）和LV收缩壁应力（86％）的增加。由毛细血管的Ki67染色反射的血管生成，大鼠（n = 6）增加比小鼠更多（n = 6; 10±2对6±1ki67阳性细胞/场）。用TAC（n = 4），心肌血液流量下降了55％，冠状动脉储备28％（N = 4），但它们在大鼠中保存（n = 4）。由C-kit阳性肌细胞对肌钙蛋白I染色的染色反射的Mycocesis是可以在TAC后赋予保护的另一种机制。然而，具有Tac的大鼠中的C-kit阳性细胞对于肌钙蛋白I负都是阴性的，表明没有肌钙生成。因此，与小鼠相比，大鼠对严重压力过载具有相对耐受性，其具有涉及血管生成而不是肌肉生成的机制。

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