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首页> 外文期刊>American Journal of Physiology >Are interstitial cells of Cajal plurifunction cells in the gut?
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Are interstitial cells of Cajal plurifunction cells in the gut?

机译：在肠道中是cajal多功能细胞的间质细胞吗？

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First published October 11, 2007; doi:10.1152/ajpgi.00344.2007.-The proposed functions of the interstitial cells of Cajal (ICC) are to 1) pace the slow waves and regulate their propagation, 2) mediate enteric neuronal signals to smooth muscle cells, and 3) act as mechanosensors. In addition, impairments of ICC have been implicated in diverse motility disorders. This review critically examines the available evidence for these roles and offers alternate explanations. This review suggests the following: 1) The ICC may not pace the slow waves or help in their propagation. Instead, they may help in maintaining the gradient of resting membrane potential (RMP) through the thickness of the circular muscle layer, which stabilizes the slow waves and enhances their propagation. The impairment of ICC destabilizes the slow waves, resulting in attenuation of their amplitude and impaired propagation. 2) The one-way communication between the enteric neuronal varicosities and the smooth muscle cells occurs by volume transmission, rather than by wired transmission via the ICC. 3) There are fundamental limitations for the ICC to act as mechanosensors. 4) The ICC impair in numerous motility disorders. However, a cause-and-effect relationship between ICC impairment and motility dysfunction is not established. The ICC impair readily and transform to other cell types in response to alterations in their microenvironment, which have limited effects on motility function. Concurrent investigations of the alterations in slow-wave characteristics, excitation-contraction and excitation-inhibition couplings in smooth muscle cells, neurotransmitter synthesis and release in enteric neurons, and the impairment of the ICC are required to understand the etiologies of clinical motility disorders.
机译：2007年10月11日第一次出版; DOI：10.1152 / AJPGI.00344.2007。 - CAJAL（ICC）的间质细胞的建议功能为1）慢波和调节它们的繁殖，2）将肠道神经元信号介导平滑肌细胞，3）行动机械传感器。此外，ICC的损害涉及多样化的运动障碍。本综述批判性地检查了这些角色的可用证据，并提供了替代解释。此审查表明以下内容：1）ICC可能无法在传播中节省慢波或帮助。相反，它们可以帮助将静止膜电位（RMP）的梯度通过圆形肌片的厚度保持稳定慢波并增强它们的传播。 ICC的减值使慢波变得稳定，导致振幅和繁殖受损的衰减。 2）肠道神经元污染物和平滑肌细胞之间的单向通信由体积传输发生，而不是通过ICC的有线传输。 3）ICC作为机械传感器的基本限制。 4）ICC损害许多动力障碍。然而，没有建立ICC损伤和运动功能障碍之间的原因和效应关系。 ICC容易损害并响应于其微环境的改变而转化为其他细胞类型，这对动力功能有限。在平滑肌细胞中的慢波特性，激发收缩和激发抑制偶联中的改变，肠道神经元中的神经递质合成和释放以及ICC的损伤需要同时调查肠道神经元的损伤，以了解临床运动障碍的病因。

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