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首页> 外文期刊>American Journal of Physiology >Early mitral deceleration and left atrial stiffness.
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Early mitral deceleration and left atrial stiffness.

机译：早期二尖瓣减速和左心房僵硬。

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Left ventricular (LV) filling deceleration time (DT) is determined by the sum of atrial and ventricular stiffnesses (KLA + KLV). If KLA, however, is close to zero, then DT would reflect KLV only. The purpose of this study was to quantify KLA during DT. In 15 patients, KLV was assessed, immediately after cardiopulmonary bypass, from E wave DT as derived from mitral tracings obtained by transesophageal echocardiography and computed according to a validated formula. In each patient, a left atrial (LA) volume curve was also obtained combining mitral and pulmonary vein (PV) cumulative flow plus LA volume measured at end diastole. Time-adjusted LA pressure was measured simultaneously with Doppler data in all patients. KLA was then calculated during the ascending limb of the V loop and during DT. LA volume decreased by 7.3 +/- 6.5 ml/m2 during the first of mitral DT, whereas LV volume increased 9.4 +/- 8.4 ml/m2 (both P < 0.001). There was a small amount of blood coming from the PV during the same time interval, with the cumulative flow averaging 3.2 +/- 2.4 ml/m(2) (P < 0.001). Mean LA pressure was 10.0 +/- 5.1 mmHg, and it did not change during DT [from 7.8 +/- 4.3 to 8.0 +/- 4.3 mmHg, not significant (NS)], making KLA, which averaged 0.46 +/- 0.39 mmHg/ml during the V loop, close to zero during DT [KLA(DT): from -0.002 +/- 0.08 to -0.001 +/- 0.031 mmHg/ml, NS]. KLV, as assessed noninvasively from DT, averaged 0.25 +/- 0.32 mmHg/ml. In conclusion, notwithstanding the significant decrement in LA volume, KLA does not change and can be considered not different from zero during DT. Thus KLA does not affect the estimation of KLV from Doppler parameters.
机译：左心室（LV）填充减速时间（DT）由心房和心室刚度（KLA + KLV）的总和确定。然而，如果KLA接近零，则DT将仅反映KLV。本研究的目的是在DT期间量化KLA。在15名患者中，在心肺旁路后立即评估KLV，来自E波DT，从通过经细经管超声心动图获得的二尖瓣分析和根据验证的公式计算。在每位患者中，还可以在结束舒张末端测量的二尖瓣和肺静脉（PV）累积流量加仑体积的组合左心房（LA）体积曲线。在所有患者中使用多普勒数据同时测量时间调整的LA压力。然后在V环的上行肢体和DT期间计算KLA。在二尖瓣DT中，La体积减少7.3 +/- 6.5ml / m 2，而LV体积增加9.4 +/- 8.4ml / m 2（P <0.001）。在相同的时间间隔内从PV中出现少量血液，累积流量平均为3.2 +/- 2.4ml / m（2）（p <0.001）。平均La压力为10.0 +/- 5.1 mmHg，它在DT期间没有改变[从7.8 +/- 4.3至8.0 +/- 4.3 mmHg，而不是显着的（ns）]，使KLA平均为0.46 +/- 0.39 MMHG / mL在V环期间，在DT [KLA（DT）期间接近零，从-0.002 +/- 0.08至-0.001 +/- 0.031 mmhg / ml，ns]。 KLV，如非侵略性的DT评估，平均为0.25 +/- 0.32mmHg / ml。总之，尽管La体积显着下降，但KLA不会改变，并且在DT期间可以被认为与零不同。因此，KLA不会影响来自多普勒参数的KLV。

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