...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy
【24h】

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy

机译：膳食硝酸盐不会降低线粒体肌病患者的运动或改善肌肉线粒体功能的氧气成本

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Muscle weakness and exercise intolerance negatively affect the quality of life of patients with mitochondrial myopathy. Short-term dietary nitrate supplementation has been shown to improve exercise performance and reduce oxygen cost of exercise in healthy humans and trained athletes. We investigated whether 1 wk of dietary inorganic nitrate supplementation decreases the oxygen cost of exercise and improves mitochondrial function in patients with mitochondrial myopathy. Ten patients with mitochondrial myopathy (40 ± 5 yr, maximal whole body oxygen uptake = 21.2 ± 3.2 ml·min~(-1)·kg body wt~(-1), maximal work load = 122 ± 26 W) received 8.5 mg-kg body wt~(-1)-day~(-1) inorganic nitrate (~7 mmol) for 8 days. Whole body oxygen consumption at 50% of the maximal work load, in vivo skeletal muscle oxidative capacity (evaluated from postexercise phosphocreatine recovery using ~(3l)P-magnetic resonance spectroscopy), and ex vivo mitochondrial oxidative capacity in per-meabilized skinned muscle fibers (measured with high-resolution respirometry) were determined before and after nitrate supplementation. Despite a sixfold increase in plasma nitrate levels, nitrate supplementation did not affect whole body oxygen cost during sub-maximal exercise. Additionally, no beneficial effects of nitrate were found on in vivo or ex vivo muscle mitochondrial oxidative capacity. This is the first time that the therapeutic potential of dietary nitrate for patients with mitochondrial myopathy was evaluated. We conclude that 1 wk of dietary nitrate supplementation does not reduce oxygen cost of exercise or improve mitochondrial function in the group of patients tested.
机译：肌肉弱点和运动不耐受对线粒体肌病患者的生活质量产生负面影响。已显示短期膳食硝酸盐补充剂，提高健康人类和训练有素的运动员运动的运动性能，降低氧气成本。我们研究了1周的膳食无机硝酸盐补充剂是否降低了运动的氧气成本，并改善了线粒体肌病患者的线粒体功能。 10例线粒体肌病患者（40±5，最大全体氧气吸收= 21.2±3.2mL·min〜（-1）·kg体WT〜（-1），最大工作负荷= 122±26瓦）收到8.5毫克-KG体WT〜（-1） - DAY〜（-1）无机硝酸盐（〜7mmol）8天。全身氧气消耗量为50％的最大工作负荷，体内骨骼肌氧化能力（使用〜（3L）p磁共振谱的切除磷酸溶解率评估），并在每种微米的皮肤肌肉纤维中进行exvivo线粒体氧化能力（用高分辨率呼​​吸测定测量）在硝酸盐补充之前和之后测定。尽管血浆硝酸盐水平六倍，但硝酸盐补充在次数运动期间不会影响全身氧气成本。另外，在体内或离体肌肉线粒体氧化能力中没有发现硝酸盐的有益效果。这是评估膳食硝酸盐治疗线粒体肌病患者的治疗潜力。我们得出结论，1WK膳食硝酸盐补充不会降低患者在测试的患者组中的运动或改善线粒体功能的氧气成本。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号