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首页> 外文期刊>American Journal of Physiology >Female rats selectively bred for high intrinsic aerobic fitness are protectedfrom ovariectomy-associated metabolic dysfunction
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Female rats selectively bred for high intrinsic aerobic fitness are protectedfrom ovariectomy-associated metabolic dysfunction

机译：有选择性地为高固有的有氧健身造成的雌性大鼠是用卵巢切除术相关的代谢功能障碍进行保护

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Ovariectomized rodentsmodel human menopause in that they rapidly gain weight, reducespontaneous physical activity (SPA), and develop metabolic dysfunc-tion, including insulin resistance. How contrasting aerobic fitnesslevels impacts ovariectomy (OVX)-associated metabolic dysfunctionis not known. Female rats selectively bred for high and low intrinsicaerobic fitness [high-capacity runners (HCR) and low-capacity run-ners (LCR), respectively] were maintained under sedentary conditionsfor 39 wk. Midway through the observation period, OVX or sham(SHM) operations were performed providing HCR-SHM, HCR-OVX,LCR-SHM, and LCR-OVX groups. Glucose tolerance, energy expen-diture, and SPA were measured before and 4 wk after surgery, whilebody composition via dual-energy X-ray absorptiometry and adiposetissue distribution, brown adipose tissue (BAT), and skeletal musclephenotype, hepatic lipid content, insulin resistance via homeostaticassessment model of insulin resistance and AdipoIR, and blood lipidswere assessed at death. Remarkably, HCR were protected fromOVX-associated increases in adiposity and insulin resistance, ob-served only in LCR. HCR rats were —30% smaller, had ~70% greaterspontaneous physical activity (SPA), consumed —10% more relativeenergy, had greater skeletal muscle proliferator-activated receptorcoactivator 1-alpha, and —40% more BAT. OVX did not increaseenergy intake and reduced SPA to the same extent in both HCR andLCR. LCR were particularly affected by an OVX-associated reductionin resting energy expenditure and experienced a reduction in relativeBAT; resting energy expenditure correlated positively with BATacross all animals (r = 0.6; P < 0.001). In conclusion, despitereduced SPA following OVX, high intrinsic aerobic fitness protectsagainst OVX-associated increases in adiposity and insulin resistance.The mechanism may involve preservation of resting energy expendi-ture.
机译：卵巢切除啮齿动物表达人类更年期，因为它们迅速增加重量，冗长的身体活动（SPA），并开发代谢障碍物，包括胰岛素抵抗力。有氧fitnessLevels如何影响卵巢切除术（OVX），所分配的代谢功能障碍未知。为39周的久坐条件，分别选择性地育死高和低血管腺嘧啶的健身[高容量跑步者（HCR）和低容量跑步（LCR）。中途通过观察期，进行OVX或假（SHM）操作，提供HCR-SHM，HCR-OVX，LCR-SHM和LCR-OVX组。葡萄糖耐量，能量净化剂和水疗中心在手术后测量，4周期，而体组成通过双能X射线吸收术和脂肪脂肪组合物，棕色脂肪组织（BAT），肝脂肪含量，胰岛素抗性通过胰岛素抵抗和脂肪的稳态分子模型，以及死亡时评估的血脂。值得注意的是，HCR受到影响的肥胖和胰岛素抗性的相关增加，仅在LCR中使用。 HCR大鼠较小，具有〜70％的大量身体活性（SPA），消耗-10％的相对生物，具有更大的骨骼肌增殖物激活的受体转移剂1-α，蝙蝠-40％。 OVX未在HCR andlcr中均未增加摄入量和减少水疗中心在相同程度上。 LCR特别受OVX相关的减谢休息能源支出的影响，并且经历了相对条目的减少;休息的能源支出与蝙蝠罗斯所有动物（r = 0.6; p <0.001）相关联。总之，无目的凋亡的SPA，高质量的有氧健身保护伴具有肥胖性和胰岛素抵抗的高度增加的增加。机制可能涉及保存休息的能量消耗。

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