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首页> 外文期刊>American Journal of Physiology >Single-wire pressure and flow velocity measurement for quantifyingmicrovascular dysfunction in patients with coronary vasospastic angina
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Single-wire pressure and flow velocity measurement for quantifyingmicrovascular dysfunction in patients with coronary vasospastic angina

机译：冠状动脉血管族血管患者量化血管功能障碍的单线压力和流速测量

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Endothelial andvascular smooth muscle dysfunction of epicardial coronary arteriesplay a pivotal role in the pathogenesis of vasospastic angina (VSA).However, coronary microvascular (MV) function in patients withVSA is not fully understood. In the present study, subjects withoutcoronary obstruction were divided into two groups according to theacetylcholine provocation test: VSA group (n = 29) and non-VS Agroup (n = 21). Hyperemic MV resistance (hMR) was measuredusing a dual-sensor (Doppler velocity and pressure)-equipped guide-wire, and guidewire-derived hemodynamic parameters were com-pared. There were no between-group differences in clinical demo-graphics, including potential factors affecting MV function (e.g.,diabetes). Although coronary flow velocity reserve was similar be-tween the two groups [2.4 ±1.0 (VSA group) vs. 2.4 ± 0.9 (non-VSAgroup); P = 0.8], coronary vessel resistance and hMR were signifi-cantly elevated in the VSA group compared with the non-VSA group(2.6 ± 3.1 vs. 1.2 ± 0.8, P = 0.04; 1.9 ± 0.6 vs. 1.6 ± 0.5, P = 0.03,respectively). Coronary vasospasm, older age, E/e’, and estimatedglomerular filtration rate were significantly associated with MV dys-function [defined as s median value of hMR (1.6)] in univariateanalysis. Coronary vasospasm most strongly predicted higher hMR inmultivariate logistic regression analysis (odds ratio, 4.61; 95% con-fidence interval, 0.98-21.60; P = 0.053). In conclusion, coronary MVresistance is impaired in patients with VSA compared with non-VSApatients, whereas coronary flow velocity reserve is maintained atnormal levels in both groups. In vivo assessment of hMR might be apromising index of coronary MV dysfunction in patients with VSA.
机译：心外膜血管平滑肌功能障碍表皮冠状动脉间隙术枢轴作用在旋转痉挛性心绞痛（VSA）的发病机制中。无论何种，患者都没有完全理解患者患者冠状动脉微血管（MV）功能。在本研究中，受试者根据紫红石挑衅试验（N = 29）和非对Agroup（n = 21）分为两组的受试者。测量二次传感器（多普勒速度和压力） - 易用的导丝和导丝血液动力学参数的血液发射MV电阻（HMR）。临床演示 - 图形中没有之间的差异，包括影响MV功能的潜在因素（例如，糖尿病）。虽然冠状动脉速率储备类似于两组[2.4±1.0（VSA组）与2.4±0.9（非VsAgroup）;与非VSA组相比，冠状动脉血管抗性和HMR在VSA组中显着升高（2.6±3.1与1.2±0.8，P = 0.04; 1.9±0.6 Vs. 1.6±0.5，P = 0.03分别）。冠状动脉血管痉挛，年龄较大，E / E'和估计凝血过滤率与单次单次分析中的MV Dys-函数显着相关[定义为HMR（1.6）的S中位值]。冠状动脉血管痉挛最强烈地预测HMR较高的HMR inmultiatiate Logistic回归分析（赔率比，4.61; 95％Con-Fent间隔，0.98-21.60; P = 0.053）。总之，与非vsapatients相比，VSA患者患者冠状动脉MVResistance损害，而冠状动脉流速储备在这两个群体中保持着腹部水平。体内评估HMR可能是VSA患者冠状动物MV功能障碍的不评指标。

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