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Carbon monoxide in the treatment of sepsis

机译：一氧化碳在治疗败血症中

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Carbon monoxide (CO), a low-molecular-weight gas, is endogenously produced in the body as a product of heme degradation catalyzed by heme oxygenase (HO) enzymes. As the beneficial roles of HO system have been elucidated in vitro and in vivo, CO itself has also been reported as a potent cytoprotective molecule. Whereas CO represents a toxic inhalation hazard at high concentration, low-dose exogenous CO treatment (~250-500 parts per million) demonstrates protective functions including but not limited to the anti-inflammatory and antiapo-ptotic effects in preclinical models of human diseases. Of note, CO exposure confers protection in animal models of sepsis by inhibiting inflammatory responses and also enhancing bacterial phagocytosis in leukocytes. These unique functions of CO including both dampening inflammation and promoting host defense mechanism are mediated by multiple pathways such as autophagy induction or biosynthesis of specialized proresolving Upid mediators. We suggest that CO gas may represent a novel therapy for patients with sepsis.
机译：一氧化碳（CO），低分子量气体，在体内内源地生产，作为血红素氧合酶（HO）酶催化的血红液降解产物。随着HO系统在体外和体内阐明的有益作用，CO本身也被报告为有效的细胞保护分子。然而，CO代表高浓度的有毒吸入危害，低剂量外源CO治疗（〜250-500份）表明了保护功能，包括但不限于人类疾病的临床前模型中的抗炎和抗炎效应。作者：张莹莹，否则CO暴露通过抑制炎症反应，增强白细胞中的细菌吞噬作用，促进脓毒症的动物模型。 CO的这些独特的功能包括阻尼炎症和促进宿主防御机制介导由多种途径介导，例如自噬诱导或专门的预测uPid介质的生物合成。我们认为CO气体可能代表败血症患者的新疗法。

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