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首页> 外文期刊>American Journal of Physiology >Renal deafferentation: target for treatment of cardiovascular diseases involving sympathetic overactivity
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Renal deafferentation: target for treatment of cardiovascular diseases involving sympathetic overactivity

机译：肾Deafferentation：治疗涉及交感神经过度活动的心血管疾病的目标

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high blood pressure associated with sympathetic overactivity is often associated with cardiovascular related mortality and/or morbidity. A therapeutic approach now considered for the treatment of resistant forms of the disease involves the selective denervation of the kidney (16, 51, 52,57). Kidney function is known to be of primary importance in the long-term regulation and maintenance of arterial pressure (24). However, it is well documented that the autonomic nervous system also plays a critical role in the control of arterial pressure and in the pathogenesis of hypertension (1, 2, 36, 41), especially as it is able to modify renal function (19, 29). The autonomic nervous system and kidney are linked through renal nerves that are composed of both efferent sympathetic and afferent sensory fibers (19, 29). Although considerable evidence exists suggesting an overexcitation of the sympathetic nervous system in conjunction with neurohormonal factors in the pathogenesis of resistant forms of hypertension, these data do not unequivocally demonstrate whether the effects on arterial pressure following renal denervation are mediated by efferent renal sympathetic nerves or afferent sensory nerves originating in the kidney. This is especially true as afferent signals from the kidney alter the activity of preautonomic neurons in central sites involved in controlling arterial pressure and sympathetic nervous system activity (15), as clearly demonstrated in the article by Xu et al. (50), published in this issue of the American Journal of Physiology-Heart and Circulatory Physiology.
机译：与交感神经过敏相关的高血压通常与心血管相关的死亡率和/或发病率有关。现在考虑治疗疾病抗性形式的治疗方法涉及肾脏（16,51,52,57）的选择性去除。已知肾功能在长期调节和维持动脉压（24）中具有初步重要性。然而，有良好的记录结果，自主神经系统也在控制动脉压和高血压发病机制中起着关键作用（1,2,36,41），特别是因为它能够改变肾功能（19， 29）。自主神经系统和肾脏通过肾神经连接，这些肾神经是由散发性交感神经和传入感官纤维（19,29）组成的。虽然存在相当大的证据表明同情神经系统与神经内部因素结合在抗性形式的高血压症的发病机制中的过度抑制，但这些数据并不明确证明肾神经系统后动脉压的影响是否由viveurent肾交感神经或传入的介导源自肾脏的感觉神经。这尤其如此，作为来自肾脏的传统信号改变了在Xu等人的文章中清楚地证明了中央部位中参与的中央部位中的非发育神经元的活动（15）。 （50），发表于此问题的生理心脏和循环生理学。

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