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首页> 外文期刊>American Journal of Physiology >Reflex neuromodulation of bladder function elicited by posterior tibial nerve stimulation in anesthetized rats
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Reflex neuromodulation of bladder function elicited by posterior tibial nerve stimulation in anesthetized rats

机译：在麻醉大鼠后胫骨神经刺激引发膀胱功能的反射神经调节

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摘要

Although posterior tibial nerve stimulation (PTNS) has been shown in both clinical and animal studies to elicit bladder-inhibitory reflexes, our understanding of the role of posterior tibial nerve (PTN) afferents that elicit these responses is significantly limited. To this end, we investigated the effects of frequency-dependant PTNS in urethane-anesthe-tized rats undergoing repeated urodynamic fills. Nerve stimulation trials (10 min) resulted in statistically significant inhibition of the urinary bladder, both during and after nerve stimulation (P < 0.05). PTNS applied at 5 Hz resulted in both acute and prolonged changes that corresponded to 38.0% and 34.1% reductions in the bladder contraction frequency, respectively. In contrast, PTNS applied at 10 Hz could only elicit an acute decrease (22.9%) in bladder activity. Subsequent electrical activation of individual PTN branches (lateral or medial plantar nerves) confirmed that these bladder reflexes are mediated by specific subsets of the PTN trunk. Both acute and prolonged inhibition of the bladder were achieved by electrical stimulation of the lateral plantar (10 and 20 Hz) and medial plantar (5 and 10 Hz) nerves. Finally, we report a bladder-excitatory reflex that is elicited by electrical activation of either the PTN trunk or lateral plantar nerve at 50 Hz. This study shows that multiple bladder reflexes are tuned to specific subsets of nerve afferents and stimulation frequencies, each of which provide novel insights into the physiological effects of PTNS.
机译：虽然后胫骨神经刺激（PTNS）已经显示在临床和动物研究中，以引发膀胱抑制反射，但我们对引发这些反应的后胫神经（PTN）引入的作用的理解得到了明显的限制。为此，我们研究了频率依赖性PTN在经历重复尿动力学填充的氨基甲酸酯吞噬型大鼠中的影响。神经刺激试验（10分钟）导致神经刺激期间和后尿膀胱的统计学显着抑制（P <0.05）。 PTN在5 Hz施用，导致急性和长时间变化，分别与膀胱收缩频率的38.0％和34.1％降低。相反，在10 Hz施用的PTN只能引发膀胱活性的急性下降（22.9％）。随后的单个PTN分支（横向或内侧跖部）的电激活证实，这些膀胱反射由PTN躯干的特定子集介导。通过侧向跖跖（10和20 Hz）和内侧跖（5和10 Hz）神经的电刺激来实现膀胱急性和长期抑制。最后，我们报告了一种膀胱兴奋剂反射，其通过在50Hz处的PTN躯干或侧跖姿的电气激活引发。该研究表明，多种膀胱反射被调节给神经传统和刺激频率的特定亚群，每个血管频率都提供了对PTN的生理效果的新颖见解。

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