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首页> 外文期刊>American Journal of Physiology >Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure
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Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure

机译：血管性质的变化，而不是心室性质，主要是有助于对动脉压的骨折调节

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Baroreflex modulates both the ventricular and vascular properties and stabilizes arterial pressure (AP). However, how changes in those mechanical properties quantitatively impact the dynamic AP regulation remains unknown. We developed a framework of circulatory equilibrium, in which both venous return and cardiac output are expressed as functions of left ventricular (LV) end-systolic elastance (E_(es)), heart rate (HR), systemic vascular resistance (R), and stressed blood volume (V). We investigated the contribution of each mechanical property using the framework of circulatory equilibrium. In six anesthetized dogs, we vascularly isolated carotid sinuses and randomly changed carotid sinus pressure (CSP), while measuring the LV E_(es), aortic flow, right and left atrial pressure, and AP for at least 60 min. We estimated transfer functions from CSP to E_(es), HR, R, and V in each dog. We then predicted these parameters in response to changes in CSP from the transfer functions using a data set not used for identifying transfer functions and predicted changes in AP using the equilibrium framework. Predicted APs matched reasonably well with those measured (r2 = 0.85-0.96, P < 0.001). Sensitivity analyses indicated that E_(es)and HR (ventricular properties) accounted for 14 ± 4 and 4 ± 2%, respectively, whereas R and V (vascular properties) accounted for 32 ± 4 and 39 ± 4%, respectively, of baroreflex-induced AP regulation. We concluded that baroreflex-induced dynamic AP changes can be accurately predicted by the transfer functions from CSP to mechanical properties using our framework of circulatory equilibrium. Changes in the vascular properties, not the ventricular properties, predominantly determine baroreflex-induced AP regulation.
机译：Baroreflex调节心室和血管性能并稳定动脉压（AP）。然而，这些机械性能的变化定量地影响动态AP调节仍然未知。我们开发了一种循环平衡框架，其​​中静脉返回和心脏输出既表达为左心室（LV）末端收缩弹性（E_（ES）），心率（HR），全身血管阻力（R），和压力血容量（v）。我们使用循环均衡框架调查了每个机械性能的贡献。在六只麻醉犬，我们血管分离出颈动脉鼻窦，随机改变颈动脉窦压（CSP），同时测量LV E_（ES），主动脉流动，右侧和左心房压力，AP至少60分钟。我们估计从CSP到E_（ES），HR，R和V中的转移函数。然后，我们响应于使用不用于识别传输函数的数据集并使用均衡框架预测AP的预测变化，响应于CSP的变化来预测这些参数。预测的APS与测量的那些相匹配（R2 = 0.85-0.96，P <0.001）。敏感性分析表明，e_（ES）和HR（心室性能）分别占Baroreflex的32±4和39±4％，分别占14±4和4±2％ - 诱导的AP规则。我们得出结论，通过使用我们的循环平衡框架，可以通过从CSP到机械性能的传递函数来准确地预测aroreflex诱导的动态AP变化。血管性质的变化，而不是心室性质，主要决定了Baroreflex诱导的AP调节。

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