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首页> 外文期刊>American Journal of Physiology >Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity
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Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity

机译：尽管减少了肥胖，但仍保留久坐不动肥胖内脏白色脂肪组织表型，尽管肥胖降低

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摘要

Regular physical activity is effective in reducing visceral white adipose tissue (AT) inflammation and oxidative stress, and these changes are commonly associated with reduced adiposity. However, the impact of multiple periods of physical activity, intercalated by periods of inactivity, i.e., intermittent physical activity, on markers of AT inflammation and oxidative stress is unknown. In the present study, 5-wk-old male C57BL/6 mice were randomized into three groups (n = 10/group): sedentary, regular physical activity, and intermittent physical activity, for 24 wk. All animals were singly housed and fed a diet containing 45% kcal from fat. Regularly active mice had access to voluntary running wheels throughout the study period, whereas intermittently active mice had access to running wheels for 3-wk intervals (i.e., 3 wk on/3 wk off) throughout the study. At death, regular and intermittent physical activity was associated with similar reductions in visceral AT mass (approximately —24%, P < 0.05) relative to sedentary. However, regularly, but not intermittently, active mice exhibited decreased expression of visceral AT genes related to inflammation (e.g., mono-cyte chemoattractant protein 1), immune cell infiltration (e.g., CD68, CDllc, F4/80, CDllb/CD18), oxidative stress (e.g., p47 phagocyte oxidase), and endoplasmic reticulum stress (e.g., CCAAT enhancer-binding protein homologous protein; all P < 0.05). Furthermore, regular, but not intermittent, physical activity was associated with a trend toward improvement in glucose tolerance (P = 0.059). Collectively, these findings suggest that intermittent physical activity over a prolonged period of time may lead to a reduction in adiposity but with retention of a sedentary obese white AT and metabolic phenotype.
机译：定期的物理活性可有效地减少内脏白色脂肪组织（AT）炎症和氧化应激，并且这些变化通常与降低的肥胖相关。然而，在炎症和氧化应激的标志物上，通过不活跃的时期的多个身体活性的影响，即间歇性身体活性均为未知。在本研究中，将5-WK-γ雄性C57BL / 6小鼠随机分为三组（n = 10 /组）：久入，常规体育活动和间歇性身体活动，24周。所有动物都被单独饲养并喂食含有45％Kcal的饮食。定期活动的小鼠可以在整个研究期间获得自愿运行轮，而间歇性的小鼠在整个研究中可以访问运行车轮（即，3周，3周，3周期/ 3 WK OFF）。在死亡时，定期和间歇性的身体活性与相对于久入性的质量（约-24％，P <0.05）的内脏的类似减少相关。然而，定期但不间断地，活性小鼠表现出与炎症（例如单细胞趋化蛋白1），免疫细胞浸润（例如，CD68，CD11，F4 / 80，CD11B / CD18）的相关基因表达下降的表达下降氧化应激（例如，P47吞噬细胞氧化酶）和内质网应激（例如，CCAAT增强子结合蛋白质同源蛋白质;所有P <0.05）。此外，常规但不间歇性的身体活性与葡萄糖耐量的改善趋势相关（P = 0.059）。总的来说，这些研究结果表明，在长时间间歇性的身体活动可能导致肥胖的降低，但保留了久坐不动的肥胖白色和代谢表型。

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