• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology
【24h】

Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology

机译：急性和慢性心力衰竭病理学中的心肌凸起和心肺网络的心功能和结构纲要

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Heart failure (HF) secondary to myocardial infarction (MI) is linked to kidney complications that comprise cellular, structural, functional, and survival indicators. However, HF research is focused on left ventricular (LV) pathology. Here, we determined comprehensive functional analysis of the LV using echo-cardiography in transition from acute heart failure (AHF) to progressive chronic heart failure (CHF) pathology and developed a histolog-ical compendium of the cardiosplenic and cardiorenal networks in pathological remodeling. In surgically induced MI using permanent coronary ligation, the LV dysfunction is pronounced, with myocardium necrosis, wall thinning, and 20-30% LV rupture events that indicated AHF and CHF pathological remodeling in C57BL/6 male mice (2-4 mo old, n = 50). Temporal LV function analysis indicated that fractional shortening and strain are reduced from day 1 to day 5 in AHF and sustained to advance to CHF from day 28 to day 56 compared with naive control mice (n = 6). During the transition of AHF (day 1 to day 5) to advanced CHF (day 28 to day 56), histological and cellular changes in the spleen were definite, with bimodal inflammatory responses in kidney inflammatory biomarkers. Likewise, there was a unidirectional, progressive, and irreversible deposition of compact collagen in the LV along with dynamic changes in the cardiosplenic and cardiorenal networks post-MI. The renal histology and injury markers suggested that cardiac injury triggers irreversible dysregulation that actively alters the cardiosplenic and cardiorenal networks. In summary, the novel strategies or pathways that modulate comprehensive cardiosplenic and cardiorenal networks in AHF and CHF would be effective approaches to study either cardiac repair or cardiac pathology.
机译：心肌梗死（MI）中的心力衰竭（MI）与肾并发症相关，其包含细胞，结构，功能和存活指标。然而，HF研究重点是左心室（LV）病理学​​。在这里，我们使用从急性心力衰竭（AHF）转换到渐进式慢性心力衰竭（CHF）病理学的回声心脏造影来确定综合性功能分析，并在病理重塑中开发了一种神经凸起和心肺网络的组织学 - ICE纲要。在手术诱导的MI使用永久性冠状动脉结扎，LV功能障碍被发音，心肌坏死，壁稀释和20-30％的LV破裂事件，指示AHF和CHF病理改造在C57BL / 6雄性小鼠（2-4莫老）中（2-4莫老） n = 50）。时间LV函数分析表明，与幼稚对照小鼠（n = 6）相比，分数缩短50天至第5天和第28天至第56天持续预先进入CHF。在AHF（第1天至第5天）的转变期间至高级CHF（第28天至第56天），脾脏中的组织学和细胞变化是明确的，在肾炎生物标志物中具有双峰炎性反应。同样地，LV中的紧凑型胶原蛋白的单向，渐进性和不可逆性和不可逆转的沉积以及MI后心肌凸起和心肺网络的动态变化。肾组织学和损伤标记表明，心脏损伤触发不可逆的失呼量，积极改变有表现性和生物网络。总之，调节AHF和CHF中综合性有表现和心肺网络的新型策略或途径将是研究心脏修复或心脏病学的有效方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号