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首页> 外文期刊>American Journal of Physiology >Pharmacological regulation of outflow resistance distal to Schlemm's canal
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Pharmacological regulation of outflow resistance distal to Schlemm's canal

机译：对施李姆运河远端流出抗性的药理调节

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The trabecular meshwork (TM) and Schlemm's canal generate the majority of outflow resistance; however, the distal regions of the conventional outflow pathway account for 25-50% of total resistance. Sections of distal vessels are surrounded by ?smooth muscle actin-containing cells, indicating that they may be vasoregulated. This study examined the effect of a potent vasodilator, nitric oxide (NO), and its physiological antagonist, endothelin-1 (ET-1), on the regulation of outflow resistance in the distal regions of the conventional outflow pathway. Using a physiological model of the conventional outflow pathway, human and porcine anterior segments were perfused in organ culture under constant flow conditions, while intrachamber pressure was continually monitored. For porcine anterior segments, a stable baseline outflow facility with TM intact was first achieved before anterior segments were removed and a trabeculotomy was performed. For human anterior segments, a trabeculotomy was immediately performed. In human anterior segments, 100 nM ET-1 significantly decreased distal outflow facility from 0.49 ?0.26 to 0.31 ?0.18 (mean ?SD) 糽穖in~(-1)mmHg, P < 0.01. Perfusion with 100 糓 diethylenetriamine-NO in the presence of 1 nM ET-1 immediately reversed ET-1 effects, significantly increasing distal outflow facility to 0.54 ?0.35 糽穖in~(-1)mmHg, P = 0.01. Similar results were obtained in porcine anterior segment experiments. Therefore, data show a dynamic range of resistance generation by distal vessels in both the human and the porcine conventional outflow pathways. Interestingly, maximal contraction of vessels in the distal outflow tract of trabecu-lotomized eyes generated resistance very near physiological levels for both species having an intact TM.
机译：小梁网状（TM）和Schlemm的运河产生大部分流出抵抗力;然而，传统流出路径的远端区域占总电阻的25-50％。远端血管的部分包围？平滑肌含有型肌动蛋白的细胞，表明它们可以是血管造粒的。该研究检测了有效的血管舒张，一氧化氮（NO）及其生理拮抗剂内皮素-1（ET-1）对常规流出途径的远端区域的流出抗性调节的影响。使用常规流出途径的生理模型，在恒定流动条件下在器官培养中灌注人和猪前段，而持续的内避压压力是不断监测的。对于猪前段，首先在除去前段之前实现具有Tm完整的稳定基线流出设施，并且进行了进行了进行了TrabeculoTomy。对于人前段，立即进行TrabeculoTomy。在人体前段中，100nm ET-1从0.49〜0.26至0.31〜0.26至0.31×0.18（平均值），P <0.01中的远端流出设施显着降低。灌注100‰二亚乙基三胺 - 在1nm ET-1存在下立即反转ET-1效果，显着增加远端流出设施至0.54〜0.35‰〜（-1）mmHg，p = 0.01。在猪前段实验中获得了类似的结果。因此，数据显示了人和猪常规流出路径中的远端血管产生的动态抗性范围。有趣的是，在Trabecu - 奖金眼中的远端流出条件中的容器的最大收缩产生了完整Tm的两种物种的抵抗力非常接近生理水平。

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