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首页> 外文期刊>American Journal of Physiology >Targeting pain at its source in sickle cell disease
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Targeting pain at its source in sickle cell disease

机译：在镰状细胞疾病中瞄准其来源的痛苦

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摘要

Sickle cell disease (SCD) is a genetic disorder associated with hemolytic anemia, end-organ damage, reduced survival, and pain. One of the unique features of SCD is recurrent and unpredictable episodes of acute pain due to vasoocclusive crisis requiring hospitalization. Additionally, patients with SCD often develop chronic persistent pain. Currently, sickle cell pain is treated with opioids, an approach limited by adverse effects. Because pain can start at infancy and continue throughout life, preventing the genesis of pain may be relatively better than treating the pain once it has been evoked. Therefore, we provide insights into the cellular and molecular mechanisms of sickle cell pain that contribute to the activation of the somatosensory system in the peripheral and central nervous systems. These mechanisms include mast cell activation and neurogenic inflammation, peripheral nociceptor sensitization, maladaptation of spinal signals, central sensitization, and modulation of neural circuits in the brain. In this review, we describe potential preventive/therapeutic targets and their targeting with novel pharmacologic and/or integrative approaches to ameliorate sickle cell pain.
机译：镰状细胞疾病（SCD）是与溶血性贫血，末端器官损伤，减少存活和疼痛相关的遗传疾病。 SCD的独特功能之一是由于需要住院治疗的巨型危险危机而具有反复性和不可预测的急性疼痛事件。此外，SCD的患者通常会产生慢性持续的疼痛。目前，镰状细胞疼痛用阿片类药物处理，一种受不良反应的方法。因为疼痛可以从婴儿期开始并在整个生命中持续，但预防疼痛的起源可能比治疗疼痛一旦被唤起。因此，我们提供了对镰状细胞疼痛的细胞和分子机制的见解，这有助于激活外周和中枢神经系统的躯体感受系统。这些机制包括肥大细胞活化和神经源性炎症，外周伤害症致敏，脊柱信号的不良机，中央致敏和脑中神经电路的调节。在本文中，我们描述了潜在的预防/治疗目标及其与新药理学和/或综合方法的靶向，以改善镰状细胞疼痛。

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