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首页> 外文期刊>American Journal of Physiology >Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver
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Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver

机译：运动培训减少了人们的肝内脂质含量和没有非酒精脂肪肝的人

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Exercise training reduces intrahepatic lipid (IHL) content in people with elevated liver fat content. It is unclear, however, whether exercise training reduces IHL content in people with normal liver fat content. Here, we measured the effect of exercise training on IHL content in people with and people without nonalcohol fatty liver. We further measured changes in insulin sensitivity and hepatic energy metabolism. Eleven males with nonalcoholic fatty liver (NAFL) and 11 body mass index-matched individuals without nonalcoholic fatty liver (CON) completed a 12-wk supervised exercise training program. IHL content (proton magnetic resonance spectroscopy), maximal oxidative capacity (VO_(2max), spiroergometry), total muscle strength, body composition, insulin sensitivity (hyperinsulinemic-euglycemic clamp), hepatic ATP-to-total phosphorus ratio, and the hepatic phos-phomonoester-to-phosphodiester (PME/PDE) ratio (phosphorus magnetic resonance spectroscopy) were determined. IHL content reduced with exercise training (P = 0.014) in the whole study population. The relative reduction in IHL content was comparable in NAFL (—34.5 ± 54.0%) and CON (-28.3 ± 60.1%) individuals (P = 0.800). Vo_(2max),x (P < 0.001), total muscle strength (P < 0.001), and skeletal muscle insulin sensitivity (P = 0.004) increased, whereas adipose tissue (P = 0.246) and hepatic (P = 0.086) insulin sensitivity did not increase significantly. Hepatic ATP-to-total phosphorus ratio (P = 0.987) and PME/PDE ratio (P = 0.792) did not change. Changes in IHL content correlated with changes in body weight (r = 0.451, P = 0.035) and changes in hepatic PME/PDE ratio (r = 0.569, P = 0.019). In conclusion, exercise training reduced intrahepatic lipid content in people with nonalcoholic fatty liver and in people with normal intrahepatic lipid content, and the percent reduction in intrahepatic lipid content was similar in both groups.
机译：运动训练减少了肝脂肪含量升高的人中的肝内脂质（IHL）含量。然而，尚不清楚运动培训是否降低了具有正常肝脏脂肪含量的人们的IHL含量。在这里，我们测量了运动训练对没有非酒精脂肪肝的人的IHL含量的影响。我们进一步测量了胰岛素敏感性和肝能代谢的变化。 11种患有非酒精性脂肪肝（NAFL）和11个体重指数匹配的个体，没有非酒精性脂肪肝（CON）完成了12-WK监督的运动培训计划。 IHL含量（质子磁共振谱），最大氧化能力（VO_（2max），螺旋液计，肌肌强度，身体组成，胰岛素敏感性（高胰岛素血症 - EGGLYCEX钳），肝脏ATP至总磷比和肝脏磷酸测定磷酸酯 - 磷酸二酯（PME / PDE）比（磷磁共振光谱）。在整个研究人群中，IHL内容随着运动训练（P = 0.014）减少。在NaF1（-34.5±54.0％）中，IHL含量的相对降低相当（-28.3±60.1％）个体（p = 0.800）。 VO_（2max），X（P <0.001），总肌肉强度（P <0.001），骨骼肌胰岛素敏感性（P = 0.004）增加，而脂肪组织（P = 0.246）和肝（P = 0.086）胰岛素敏感性没有显着增加。肝脏ATP-总磷比（P = 0.987）和PME / PDE比（P = 0.792）没有变化。与体重变化（r = 0.451，p = 0.035）相关的IHL含量的变化以及肝PME / PDE比的变化（r = 0.569，p = 0.019）。总之，运动培训与非酒精性脂肪肝的人类肝内脂肪含量和正常的肝内脂质含量的人的培训减少，并且两组中，肝内脂质含量的减少百分比相似。

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