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首页> 外文期刊>American Journal of Physiology >The prorenin receptor in the cardiovascular system and beyond
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The prorenin receptor in the cardiovascular system and beyond

机译：心血管系统和超越的prorenin受体

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Since the prorenin receptor (PRR) was first reported, its physiological role in many cellular processes has been under intense scrutiny. The PRR is currently recognized as a multifunctional receptor with major roles as an accessory protein of the vacuolar-type H+-ATPase and as an intermediary in the Wnt signaling pathway. As a member of the renin-angiotensin system (RAS), the PRR has demonstrated to be of relevance in cardiovascular diseases (CVD) because it can activate prorenin and enhance the enzymatic activity of renin, thus promoting angiotensin II formation. Indeed, there is an association between PRR gene polymorphisms and CVD. Independent of angiotensin II, the activation of the PRR further stimulates intra-cellular signals linked to fibrosis. Studies using tissues and cells from a variety of organs and systems have supported its roles in multiple functions, although some remain controversial. In the brain, the PRR appears to be involved in the central regulation of blood pressure via activation of RAS- and non-RAS-dependent mechanisms. In the heart, the PRR promotes atrial structural and electrical remodeling. Nonetheless, animals overexpressing the PRR do not exhibit cardiac injury. In the kidney, the PRR is involved in the development of ureteric bud branching, urine concentration, and regulation of blood pressure. There is great interest in the PRR contributions to T cell homeostasis and to the development of visceral and brown fat. In this mini-review, we discuss the evidence for the pathophysiological roles of the PRR with emphasis in CVD.
机译：由于首次报道了Prorenin受体（PRR），因此在许多细胞过程中的生理作用一直受到强烈的审查。该PRR目前被认为是具有主要作用的多功能受体，作为真空型H + -ATP酶的辅助蛋白质和作为WNT信号传导途径中的中间体。作为肾素 - 血管紧张素系统（RAS）的成员，PRR已经证明在心血管疾病（CVD）中具有相关性，因为它可以激活prorenin并增强肾素的酶活性，从而促进血管紧张素II形成。实际上，PRR基因多态性和CVD之间存在关联。独立于血管紧张素II，PRR的激活进一步刺激与纤维化有关的细胞内信号。使用来自各种器官和系统的组织和细胞的研究支持了多种功能中的作用，尽管有些仍然存在争议。在大脑中，PRR似乎通过激活RAS和非RAS依赖机制涉及血压的中心调节。在心脏中，PRR促进心房结构和电气重塑。尽管如此，过表达PRR的动物不会表现出心脏损伤。在肾脏中，PRR参与了输尿管芽分支，尿液浓度和血压调节的发展。对T细胞稳态的PRR贡献非常兴趣，并发展了内脏和棕色脂肪的发展。在这个迷你审查中，我们讨论了PRR的病理生理角色在强调CVD的证据。

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