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The dawn of succinylation: a posttranslational modification

机译:琥珀酰胺的曙光:一种后期改性

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Posttranslational modifications affect almost all proteins and are critical to a well-functioning and diverse proteome; however, many modifications remain relatively unknown and unstudied. This paper will give a perspective on the rapidly developing, novel posttranslational modification called succinylation. This modification may be implicated in numerous diseases, such as hepatic, cardiac, and pulmonary diseases. Although the influences of this modification still remain poorly understood, we are confident that further research into succinylation will provide an enhanced understanding of the complex machinery within the mitochondria, as well as the imposing consequences associated with its dysfunction.
机译:后期修饰几乎影响了所有蛋白质,对良好的功能和多样化的蛋白质组至关重要; 然而,许多修改仍然相对较为未知和不含糊。 本文将在迅速发展,新的后期改变均称为琥珀酰胺化的视角。 这种修饰可以涉及许多疾病,例如肝,心脏和肺部疾病。 虽然这种修改的影响仍然仍然明白,但我们相信进一步研究琥珀酰化的研究将提供对线粒体内复杂机器的增强理解,以及与其功能障碍相关的肺部后果。

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