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首页> 外文期刊>American Journal of Physiology >Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface
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Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface

机译：硫化氢：微生物组 - 粘膜界面处的稳定剂

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摘要

A diverse range of effects of the intestinal microbiota on mucosal defense and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defense and repair. Hydrogen sulfide is produced by gastrointestinal tract tissues and by bacteria residing within the gut and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide. H_2S donors can modify the gut microbiota, and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H_2S. When administered together with nonsteroidal anti-inflammatory drugs, H_2S can prevent some of the dysbiosis those drags induce, possibly contributing to the observed prevention of gastrointestinal damage. Exogenous H_2S can also markedly reduce the severity of experimental colitis and plays important roles in modulating epithelial cell-mucus-bacterial interactions in the intestine, contributing to its ability to promote resolution of inflammation and repair of tissue injury. In this paper we review recent studies examining the roles of H_2S in mucosal defense, the possibility that H_2S can damage the gastrointestinal epithelium, and effects of H_2S on the gut microbiota and on mucus and biofilm interactions in the context of intestinal inflammation.
机译：在过去十年中，肠道微生物群对粘膜防御和伤害的各种影响变得越来越清楚。硫化氢（H2S）作为许多生理功能的重要介体，包括胃肠粘膜防御和修复。硫化氢通过胃肠道组织和栖息在肠内的细菌产生，并且可以影响各种细胞的功能。微生物液也似乎是硫化氢的重要目标。 H_2S供体可以改变肠道微生物群，胃肠上皮是微生物衍生的H_2S的主要氧化部位。当与非甾体抗炎药物一起施用时，H_2S可以防止一些脱节诱导，可能导致预防胃肠道损伤。外源性H_2S也可以显着降低实验性结肠炎的严重程度，并在调节肠中的上皮细胞 - 粘液细菌相互作用时起重要作用，有助于促进促进炎症和组织损伤修复的能力。在本文中，我们审查了最近的研究，研究了H_2S在粘膜防御中的作用，H_2S可能损害胃肠上皮的可能性，以及H_2S对肠道炎症背景下的粘液和生物膜相互作用的影响。

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