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VEGF nanoparticles repair the heart after myocardial infarction

机译：VEGF纳米粒子在心肌梗死后修复心脏

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摘要

Vascular endothelial growth factor (VEGF) is a well-characterized proan-giogenic cytokine that has been shown to promote neovascularization in hearts of patients with ischemic heart disease but can also lead to adverse effects depending on the dose and mode of delivery. We investigated whether prolonged exposure to a low dose of VEGF could be achieved by encapsulating VEGF in polylactic coglycolic acid nanoparticles and whether treatment with VEGF-containing nanoparticles improved cardiac function and protected against left ventricular remodeling in the hearts of mice with experimentally induced myocardial infarction. Polylactic coglycolic acid nanoparticles with a mean diameter of -113 run were generated via double emulsion and loaded with VEGF; the encapsulation efficiency was 53.5 ± 1.7% (107.1 ± 3.3 ng VEGF/mg nanoparticles). In culture, VEGF nanoparticles released VEGF continuously for at least 31 days, and in a murine myocardial infarction model, VEGF nanoparticle administration was associated with significantly greater vascular density in the peri-infarct region, reductions in infarct size, and improvements in left ventricular contractile function 4 wk after treatment. Thus, our study provides proof of principle that nanoparticle-mediated delivery increases the angiogenic and therapeutic potency of VEGF for the treatment of ischemic heart disease.
机译：血管内皮生长因子（VEGF）是一种特征在于一种良好的促致致态细胞因子，已被证明可以在缺血性心脏病患者的心中促进新生血管化，但也可以取决于剂量和递送方式导致不利影响。我们研究了通过在聚乳酸果糖酸纳米粒子中包封VEGF和是否用VEGF的纳米颗粒进行治疗来实现延长延长对低剂量的VEGF的延长暴露，并在通过实验诱导的心肌梗死的小鼠心脏中抗心脏功能并防止左心室重塑。通过双乳液产生平均直径为-113运行的聚乳糖酸纳米颗粒，并用VEGF加载;封装效率为53.5±1.7％（107.1±3.3 ng VEGF / Mg纳米粒子）。在培养中，VEGF纳米颗粒连续释放VEGF至少31天，并且在小鼠心肌梗死模型中，VEGF纳米粒子施用与PERI-IMARCT区域中的血管密度明显更大，梗塞大小减少，左心室收缩的改善治疗后功能4周。因此，我们的研究提供了原则上的证据，即纳米粒子介导的递送增加了VEGF治疗缺血性心脏病的血管生成和治疗效力。

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