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Impact of estrogens and estrogen receptor-a in brain lipid metabolism

机译:雌激素和雌激素受体-A在脑脂代谢中的影响

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摘要

Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known lhat lack of estrogens promotes increased food intake and induces the expansion of adipose tissues, for which much is known. An area of estrogenic research that has received less attention is the role of estrogens and their receptors in influencing intermediary lipid metabolism in organs such as the brain. In this review, we highlight the actions of estrogens and their receptors in regulating their impact on modulating fatty acid content, utilization, and oxidation through their direct impact on intracellular signaling cascades within the central nervous system.
机译:雌激素及其受体在调节体重,能源支出和代谢稳态方面发挥关键作用。 已知Lhat缺乏雌激素促进食物摄入量增加,并诱导脂肪组织的扩增,其众所周知。 雌激素研究领域已受到较少关注的是雌激素及其受体在影响诸如脑中的器官中的中间脂质代谢方面的作用。 在本文中,我们突出了雌激素及其受体在调节其对调节脂肪酸含量,利用和氧化的影响,通过直接影响中枢神经系统内的细胞内信号级联来调节它们的影响。

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