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Role of adaptor protein p66Shc in renal pathologies

机译:适配器蛋白P66SHC在肾病中的作用

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摘要

p66Shc is one of the three adaptor proteins encoded by the Slid gene, which are expressed in many organs, including the kidney. Recent studies shed new light on several key questions concerning the signaling mechanisms mediated by p66Shc. The central goal of this review article is to summarize recent findings on p66Shc and the role it plays in kidney physiology and pathology. This article provides a review of the various mechanisms whereby p66Shc has been shown to function within the kidney through a wide range of actions. The mitochondrial and cytoplasmic signaling of p66Shc, as it relates to production of reactive oxygen species (ROS) and renal pathologies, is further discussed.
机译:P66SHC是由SLID基因编码的三种适配器蛋白之一,其在许多器官中表达,包括肾脏。 最近的研究揭示了关于P66SHC介导的信号传导机制的几个关键问题。 本综述文章的核心目标是总结最近关于P66SHS的结果和它在肾生理学和病理学中发挥的作用。 本文提供了对各种机制的审查,其中P66SHC已被证明通过广泛的行动在肾脏内运作。 进一步讨论了P66SHC的线粒体和细胞质信号传导,因为它涉及反应性氧物质(ROS)和肾病理学的生产。

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