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首页> 外文期刊>American Journal of Physiology >Insulin increases ventilation during euglycemia in humans
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Insulin increases ventilation during euglycemia in humans

机译：胰岛素在人类的euglycemia期间增加了通风

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Evidence from animal studies indicates that hyperinsulinemia, without changes in glucose, increases ventilation via a carotid body-mediated mechanism. However, whether insulin elevates ventilation in humans independently of changes in glucose remains unclear. Therefore, we tested the hypothesis that insulin increases ventilation in humans during a hyperinsulinemic-euglycemic clamp in which insulin was elevated to postprandial concentrations while glucose was maintained at fasting concentrations. First, in 16 healthy young men (protocol J), we retrospectively analyzed respiration rate and estimated tidal volume from a pneumobelt to calculate minute ventilation during a hyperinsulinemic-euglycemic clamp. In addition, for a direct assessment of minute ventilation during a hyperinsulinemic-euglycemic clamp, we retrospectively analyzed breath-by-breath respiration rate and tidal volume from inspired/expired gasses in an additional 23 healthy young subjects (protocol 2). Clamp infusion elevated minute ventilation from baseline in both protocols (protocol 1: +11.9 + 4.6% baseline, P = 0.001; protocol 2: +9.5 ± 3.8% baseline, P = 0.020). In protocol 1, peak changes in both respiration rate (+13.9 ± 3.0% baseline, P < 0.001) and estimated tidal volume (+16.9 ±4.1% baseline, P = 0.001) were higher than baseline during the clamp. In protocol 2, tidal volume primarily increased during the clamp ( + 9.7 ± 3.7% baseline, P = 0.016), as respiration rate did not change significantly (+0.2 ± 1.8% baseline, P = 0.889). Collectively, we demonstrate for the first time in humans that elevated plasma insulin increases minute ventilation independent of changes in glucose.
机译：来自动物研究的证据表明，在没有葡萄糖的情况下，高胰岛素血症通过颈动脉体介导的机制增加通风。然而，胰岛素是否升高人类的通风，独立于葡萄糖的变化仍然不清楚。因此，我们测试了胰岛素在高胰岛素血症 - 神经血糖夹持过程中增加了人类的通风，其中胰岛素升高到餐后浓度，而葡萄糖保持在禁食浓度下。首先，在16名健康的年轻男性（协议J）中，我们回顾性地分析了呼吸率和估计从肺炎塞尔估计的潮气量，以计算高胰岛素血症 - 神血血糖夹持过程中的微小通风。此外，对于在高胰岛素血症 - 可血糖夹持过程中的微小通气的直接评估，我们回顾性地分析了呼吸呼吸呼吸率和潮气体积，在另外的23个健康的年轻受试者中受到启发/过期的气体（协议2）。夹紧输注在两种方案中从基线升高的微小通风（协议1：+11.9 + 4.6％基线，P = 0.001;协议2：+ 9.5±3.8％基线，P = 0.020）。在方案1中，呼吸率（+13.9±3.0％基线，P <0.001）和估计潮气量（+16.9±4.1％基线，P = 0.001）的峰值变化高于夹子期间的基线。在协议2中，潮气量在夹层期间增加（+ 9.7±3.7％基线，P = 0.016），因为呼吸速率没有显着变化（+0.2±1.8％基线，P = 0.889）。总的来说，我们在人类中首次证明了升高的血浆胰岛素增加了几乎没有葡萄糖的变化的微小通风。

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