• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Effect of dietary palmitic and stearic acids on sucrose motivation and hypothalamic and striatal cell signals in the rat
【24h】

Effect of dietary palmitic and stearic acids on sucrose motivation and hypothalamic and striatal cell signals in the rat

机译：饮食棕榈和硬脂酸对大鼠蔗糖动机和下丘脑和裂纹细胞信号的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have reported that motivation for sucrose is increased in rats fed a moderate (31%) mixed-fat diet for 4-6 wk. In this study, rats were fed diets containing 32% stearic (STEAR) or palmitic (PALM) acid, and behavior, metabolic profile, and cell signals were compared with those of rats fed a matched low-fat diet (LF; 11 % fat) diet. Rats fed STEAR or PALM increased sucrose motivation relative to LF rats (one-way ANOVA for lever presses; P = 0.03). Diet did not change fasting glucose, insulin, total cholesterol, triglycerides, intravenous glucose tolerance test glucose profile, percent body fat, or total kilocalories, although kilocalories as fat were increased (ANOVA, P < 0.05). Cell signals were assessed in rats ranked from high to low sucrose motivation. Diet did not alter Thr and Ser phosphorylation of Akt in the medial hypothalamus (HYP) and striatum (STR). However, Ser phosphorylation of GSK3B was decreased in HYP and STR from both high- and low-performer tertiles of STEAR and PALM rats (ANOVA within each brain region, P < 0.05). Two histone 3 (H3) modifications were also assessed. Although there was no effect of diet on the transcription-repressive H3 modification, H3K27me3, the transcription-permissive H3 modification, H3K4me3, was significantly decreased in the HYP of high performers fed PALM or STEAR (ANOVA, P = 0.013). There was no effect of diet on H3K4me3 levels in HYP of low performers, or in STR. Our findings suggest signal-specific and brain region-specific effects of PALM or STEAR diets and may link downstream signaling effects of GSK3B activity and H3 modifications with enhanced motivational behavior.
机译：我们据报道，饲喂中等（31％）混合饮食的大鼠蔗糖的动机增加4-6周。在这项研究中，将大鼠喂食含有32％硬脂酸（胫骨）或棕榈酸（棕榈）酸的饮食，并将行为，代谢谱和细胞信号与饲喂匹配的低脂肪饮食的大鼠进行比较（LF; 11％脂肪） 饮食。饲喂血糖或手掌的大鼠相对于LF大鼠的蔗糖动机（用于杠杆压力机的单向ANOVA; P = 0.03）。饮食没有改变禁食葡萄糖，胰岛素，总胆固醇，甘油三酯，静脉内葡萄糖耐量试验葡萄糖曲线，百分比体脂肪，或总千瓦，虽然千吨脂肪增加（ANOVA，P <0.05）。在从高到低蔗糖动机的大鼠中评估细胞信号。饮食未在中间下丘脑（哌啶（HYP）和纹状体（str）中改变Akt的Thr和Ser磷酸化。然而，GSK3B的Ser磷酸化在钙和低表现优于血脂和棕榈大鼠的低性表达的乳房（每个脑区内的ANOVA，P <0.05）中降低。还评估了两个组蛋白3（H3）修饰。尽管在转录 - 压抑H3修饰上没有饮食的影响，但在饲喂棕榈或血糖（ANOVA，P = 0.013）的高级表演者的HYP的H3K4ME3中，转录允许H3改性H3K4ME3的效果显着降低（ANOVA，P = 0.013）。在低表演者的H3K4ME3水平上没有饮食的影响，或者在str中。我们的研究结果表明了棕榈或血糖饮食的信号特异性和脑区特异性效果，并且可以通过增强的励磁行为将GSK3B活性的下游信号效应联系起来。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号