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首页> 外文期刊>American Journal of Physiology >Maternal stress does not exacerbate long-term bone deficits in female rats born growth restricted, with differential effects on offspring bone health
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Maternal stress does not exacerbate long-term bone deficits in female rats born growth restricted, with differential effects on offspring bone health

机译：母体压力不会加剧女性大鼠出生的长期骨缺乏，受到限制的差异，具有对后代骨骼健康的差异影响

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摘要

Females born growth restricted have poor adult bone health. Stress exposure during pregnancy increases risk of pregnancy complications. We determined whether maternal stress exposure in growth-restricted females exacerbates long-term maternal and offspring bone phenotypes. On gestational day 18, bilateral uterine vessel ligation (restricted) or sham (control) surgery was performed on Wistar-Kyoto rats. At 4 mo, control and restricted females were mated and allocated to unstressed or stressed pregnancies. Stressed pregnancies had physiological measurements performed; unstressed females were not handled. After birth, mothers were aged to 13 mo. Second-generation (F2) offspring generated four experimental groups: control unstressed, restricted unstressed, control stressed and restricted stressed. F2 offspring were studied at postnatal day 35 (PN35), 6, 12, and 16 mo. Peripheral quantitative computed tomography was performed on maternal and F2 offspring femurs. Restricted females, irrespective of stress during pregnancy, had decreased en-dosteal circumference, bending strength, and increased osteocalcin concentrations after pregnancy at 13 mo. F2 offspring of stressed mothers were bom lighter. F2 male offspring from stressed pregnancies had decreased trabecular content at 6 mo and decreased endosteal circumference at 16 mo. F2 female offspring from growth-restricted mothers had reduced cortical thickness at PN35 and reduced endosteal circumference at 6 mo. At 12 mo, females from unstressed restricted and stressed control mothers had decreased trabecular content. Low birth weight females had long-term bone changes, highlighting programming effects on bone health. Stress during pregnancy did not exacerbate these programmed effects. Male and female offspring responded differently to maternal growth restriction and stress, indicating gender-specific programming effects.
机译：女性出生的增长受限制的成年骨骼健康差。怀孕期间的压力暴露会增加妊娠并发症的风险。我们确定生长限制的女性中的母体压力暴露是否会使长期孕产妇和后代骨表型加剧。在妊娠期18天，对Wistar-kyoto大鼠进行双侧子宫血管连接（限制）或假（对照）手术。在4月份，控制和限制的女性被交配并分配给无情或强调的怀孕。强调的怀孕进行了生理测量;没有处理过的女性。出生后，母亲岁到13岁。第二代（F2）后代产生四个实验组：控制无懈可击，限制无压力，控制压力和限制压力。在产后第35天（PN35），6,12和16Mo进行F2后代。外围定量计算断层扫描是在母体和F2后代股骨上进行的。无论怀孕期间是否应激，在怀孕期间，限制雌性，在13 mo时妊娠期扭曲的圆周，弯曲强度和增加的骨钙素浓度增加。压力母亲的F2后代是BOM打火机。来自强调妊娠的F2雄性后代在6mo处具有下颌含量，并在16μm处减少了内骨膜圆周。来自生长受限制的母亲的F2女性后代在PN35的皮质厚度下降，并在6Mo处降低了内骨膜圆周。在12月12日，来自无拘无束的受限制和强调的对照母婴的女性减少了小梁内容。低出生体重女性具有长期骨骼的变化，突出了对骨骼健康的编程效果。怀孕期间的压力不会加剧这些编程的效果。男性和女性后代对孕产妇的增长限制和压力不同，表明性别特异性规划效果。

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