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首页> 外文期刊>Analytical chemistry >Novel Luminescent Nanostructured Coordination Polymer: Facile Fabrication and Application in Electrochemiluminescence Biosensor for microRNA-141 Detection
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Novel Luminescent Nanostructured Coordination Polymer: Facile Fabrication and Application in Electrochemiluminescence Biosensor for microRNA-141 Detection

机译：新型发光纳米结构配位聚合物：体积化学钻孔生物传感器的舒适性制造及应用，用于微润松-141检测

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摘要

A series of novel luminescent nanostructured coordination polymers (Ce-Ru-NCPs) with tunable morphologies have been successfully synthesized on a large scale at room temperature by a facile and rapid solution-phase method using Ce3+ and tris(4,4'-dicarboxylicacid-2,2'-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)(3)(2+)). Among them, the flowerlike Ce-Ru-NCP shows good cathodic electrochemiluminescence (ECL) characteristics. The ECL efficiency of the Ce-Ru-NCP/S(2)O(8)(2-)system is about 2.34 times that of the classic tris(2,2'-bipyridyl) ruthenium(II) dichloride/S2O82- (Ru(bpy)(3)(2+)/S2O82-) system. Hence, we report a sensitive ECL biosensor for microRNA-141 (miRNA-141) detection based on the flowerlike Ce-Ru-NCP as a cathodic ECL luminophore and a bipedal three-dimensional (3D) DNA walking machine as a signal amplifier. Through the bipedal 3D DNA walking machine, trace targets can be converted to substantial secondary targets (marked with the quencher dopamine), and a significant quenching effect on the ECL signal is achieved. As a result, the proposed biosensor exhibits a relatively good sensitivity for miRNA-141 detection and shows a dynamic range from 1.0 x 10(-16) to 1.0 x 10(-6) mol.L-1 with a limit of detection (LOD) of 33 amol.L-1 (S/N = 3). The Ce-Ru-NCP with tunable morphologies and high ECL efficiency, intensity, and stability possesses potential applications in ECL analysis.
机译：通过使用Ce3 +和Tris的容易和快速的溶液相法在室温下成功地合成了具有可调谐形态的一系列新的发光纳米结构配位聚合物（CE-Ru-NCP），通过容易和快速的溶液相方法在室温下成功地合成（4,4'-二羧酸 - 2,2'-双吡啶基）钌（II）二氯化物（Ru（DCBPY）（3）（2+））。其中，花型CE-Ru-NCP显示出良好的阴极电化学发光（ECL）特征。 Ce-Ru-NCP / s（2）O（8）（2-）系统的ECL效率为经典三（2,2'-双吡啶基）钌（II）二氯/ S2O82-（ Ru（BPY）（3）（2 +）/ S2O82-）系统。因此，我们报告了一种敏感的ECORA-141（miRNA-141）检测，基于作为阴极ECL发光电泳和作为信号放大器的双向三维（3D）DNA行走机检验的MicroRNA-141（miRNA-141）检测。通过双面3D DNA步行机，可以将痕量靶呈转换为基本的次要靶标（用猝灭剂多巴胺标记），并且实现了对ECL信号的显着淬火效应。结果，所提出的生物传感器对miRNA-141检测表现出相对较好的敏感性，并且显示出1.0×10（ - 16）至1.0×10（-6）Mol.L-1的动态范围（LOD ）33 amol.L-1（S / N = 3）。 CE-Ru-NCP具有可调谐形态和高ECL效率，强度和稳定性具有ECL分析中的潜在应用。

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  • 来源
    《Analytical chemistry》 |2020年第18期|共7页
  • 作者

    Wang Cun; Han Qian; Mo Fangjing; Chen Min; Xiong Zhengwei; Fu Yingzi;

  • 作者单位

    Southwest Univ Sch Chem &

    Chem Engn Chongqing Engn Lab Nanomat &

    Sensor Technol Chongqing 400715 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing Engn Lab Nanomat &

    Sensor Technol Chongqing 400715 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing Engn Lab Nanomat &

    Sensor Technol Chongqing 400715 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing Engn Lab Nanomat &

    Sensor Technol Chongqing 400715 Peoples R China;

    Chongqing Univ Educ Chongqing Collaborat Innovat Ctr Funct Food Chongqing 400067 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing Engn Lab Nanomat &

    Sensor Technol Chongqing 400715 Peoples R China;

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