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Bioengineering of microbial transglutaminase for biomedical applications

机译:生物医学应用微生物转酰胺酶的生物工程

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Microbial transglutaminase (mTGase) is commonly known in the food industry as meat glue due to its incredible ability to glue meat proteins together. Aside from being widely exploited in the meat processing industries, mTGase is also widely applied in other food and textile industries by catalysing the formation of isopeptide bonds between peptides or protein substrates. The advancement of technology has opened up new avenues for mTGase in the field of biomedical engineering. Efforts have been made to study the structural properties of mTGase in order to gain an in-depth understanding of the structure-function relationship. This review highlights the developments in mTGase engineering together with its role in biomedical applications including biomaterial fabrication for tissue engineering and biotherapeutics.
机译:由于其难以置信的能力在一起,因此在食品工业中常见于食品工业中的微生物转氨酰胺酶(MTGase)是肉类胶水。 除了广泛利用肉类加工行业之外,MTGase还通过催化肽或蛋白质底物之间的异肽键的形成广泛应用于其他食品和纺织工业。 技术进步在生物医学工程领域开辟了新的MTGase途径。 已经努力研究MTGase的结构性,以便深入了解结构功能关系。 本综述凸显了MTGase工程的开发,以及其在生物医学应用中的作用,包括用于组织工程和生物治疗方法的生物材料制造。

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