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Alternative strategies for the application of aminoglycoside antibiotics against the biofilm-forming human pathogenic bacteria

机译：氨基糖苷类抗生素对生物膜形成的人致病细菌施用替代策略

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摘要

Aminoglycosides are one of the common classes of antibiotics that have been widely used for treating infections caused by pathogenic bacteria. The mechanism of bactericidal action by aminoglycosides is well-known, by which it terminates the cytoplasmic protein synthesis. However, the potentials of aminoglycosides become hindered when facing the evolution of bacterial resistance mechanisms. Among multiple resistance mechanisms displayed by bacteria against antibiotics, the formation of biofilm is the mechanism that provides a barrier for antibiotics to reach the cellular level. Bacteria present in the biofilm also get protection against the impact of host immune responses, harsh environmental conditions, and other antimicrobial treatments. Hence, with the multifaceted resistance developed by biofilm-forming pathogenic bacteria, antibiotics are therefore discontinued for further applications. However, the recent research developed several alternative strategies such as optimization of the active concentration, modification of the environmental conditions, modification of the chemical structure, combinatorial application with other active agents, and formulation with biocompatible carrier materials to revitalize and exploit the new potential of aminoglycosides. The present review article describes the above mentioned multiple approaches and possible mechanisms for the application of aminoglycosides to treat biofilm-associated infections.
机译：氨基糖苷是已广泛用于治疗致病细菌引起的感染的常见抗生素的常见类别之一。通过氨基糖苷的杀菌作用机理是众所周知的，其终止于细胞质蛋白质合成。然而，在面对细菌抗性机制的演变时，氨基糖苷的潜力变得阻碍。在细菌对抗抗生素显示的多种抗性机制中，生物膜的形成是为抗生素达到细胞水平的屏障提供障碍的机制。生物膜中存在的细菌还可以保护宿主免疫应答，恶劣环境条件和其他抗微生物治疗的影响。因此，通过Biofilm形成致病细菌产生的多丝抗性，因此可以停止抗生素进行进一步的应用。然而，最近的研究开发了几种替代策略，如优化活性浓度，改性环境条件，化学结构的改性，与其他活性剂的组合应用，以及用生物相容性载体材料的配方振兴和利用新潜力氨基糖苷。本综述文章介绍了上述多种方法和应用氨基糖苷类以治疗生物膜相关感染的多种方法。

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